The bile acid receptor TGR5 does not interact with β-arrestins or traffic to endosomes but transmits sustained signals from plasma membrane rafts

Dane D. Jensen, Cody B. Godfrey, Christian Niklas, Meritxell Canals, Martina Kocan, Daniel P. Poole, Jane E. Murphy, Farzad Alemi, Graeme S. Cottrell, Christoph Korbmacher, Nevin A. Lambert, Nigel W. Bunnett, Carlos U. Corvera

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Background: The TGR5 bile acid receptor controls energy balance, inflammation, and digestion, but TGR5 signaling is poorly understood. Results: TGR5 does not interact with β-arrestins, internalize, or desensitize, but signals from plasma membrane rafts. Conclusion: TGR5 transmits sustained signals close to the cell surface. Significance: Understanding TGR5 signaling will facilitate design of TGR5 agonists for metabolic, inflammatory, and digestive disorders.

Original languageEnglish (US)
Pages (from-to)22942-22960
Number of pages19
JournalJournal of Biological Chemistry
Volume288
Issue number32
DOIs
StatePublished - Aug 9 2013

Fingerprint

Arrestins
Endosomes
Cell membranes
Bile Acids and Salts
Digestion
Cell Membrane
Inflammation
Energy balance

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

The bile acid receptor TGR5 does not interact with β-arrestins or traffic to endosomes but transmits sustained signals from plasma membrane rafts. / Jensen, Dane D.; Godfrey, Cody B.; Niklas, Christian; Canals, Meritxell; Kocan, Martina; Poole, Daniel P.; Murphy, Jane E.; Alemi, Farzad; Cottrell, Graeme S.; Korbmacher, Christoph; Lambert, Nevin A.; Bunnett, Nigel W.; Corvera, Carlos U.

In: Journal of Biological Chemistry, Vol. 288, No. 32, 09.08.2013, p. 22942-22960.

Research output: Contribution to journalArticle

Jensen, DD, Godfrey, CB, Niklas, C, Canals, M, Kocan, M, Poole, DP, Murphy, JE, Alemi, F, Cottrell, GS, Korbmacher, C, Lambert, NA, Bunnett, NW & Corvera, CU 2013, 'The bile acid receptor TGR5 does not interact with β-arrestins or traffic to endosomes but transmits sustained signals from plasma membrane rafts', Journal of Biological Chemistry, vol. 288, no. 32, pp. 22942-22960. https://doi.org/10.1074/jbc.M113.455774
Jensen, Dane D. ; Godfrey, Cody B. ; Niklas, Christian ; Canals, Meritxell ; Kocan, Martina ; Poole, Daniel P. ; Murphy, Jane E. ; Alemi, Farzad ; Cottrell, Graeme S. ; Korbmacher, Christoph ; Lambert, Nevin A. ; Bunnett, Nigel W. ; Corvera, Carlos U. / The bile acid receptor TGR5 does not interact with β-arrestins or traffic to endosomes but transmits sustained signals from plasma membrane rafts. In: Journal of Biological Chemistry. 2013 ; Vol. 288, No. 32. pp. 22942-22960.
@article{4234f5f5d94d480281eb00d6f1915825,
title = "The bile acid receptor TGR5 does not interact with β-arrestins or traffic to endosomes but transmits sustained signals from plasma membrane rafts",
abstract = "Background: The TGR5 bile acid receptor controls energy balance, inflammation, and digestion, but TGR5 signaling is poorly understood. Results: TGR5 does not interact with β-arrestins, internalize, or desensitize, but signals from plasma membrane rafts. Conclusion: TGR5 transmits sustained signals close to the cell surface. Significance: Understanding TGR5 signaling will facilitate design of TGR5 agonists for metabolic, inflammatory, and digestive disorders.",
author = "Jensen, {Dane D.} and Godfrey, {Cody B.} and Christian Niklas and Meritxell Canals and Martina Kocan and Poole, {Daniel P.} and Murphy, {Jane E.} and Farzad Alemi and Cottrell, {Graeme S.} and Christoph Korbmacher and Lambert, {Nevin A.} and Bunnett, {Nigel W.} and Corvera, {Carlos U.}",
year = "2013",
month = "8",
day = "9",
doi = "10.1074/jbc.M113.455774",
language = "English (US)",
volume = "288",
pages = "22942--22960",
journal = "Journal of Biological Chemistry",
issn = "0021-9258",
publisher = "American Society for Biochemistry and Molecular Biology Inc.",
number = "32",

}

TY - JOUR

T1 - The bile acid receptor TGR5 does not interact with β-arrestins or traffic to endosomes but transmits sustained signals from plasma membrane rafts

AU - Jensen, Dane D.

AU - Godfrey, Cody B.

AU - Niklas, Christian

AU - Canals, Meritxell

AU - Kocan, Martina

AU - Poole, Daniel P.

AU - Murphy, Jane E.

AU - Alemi, Farzad

AU - Cottrell, Graeme S.

AU - Korbmacher, Christoph

AU - Lambert, Nevin A.

AU - Bunnett, Nigel W.

AU - Corvera, Carlos U.

PY - 2013/8/9

Y1 - 2013/8/9

N2 - Background: The TGR5 bile acid receptor controls energy balance, inflammation, and digestion, but TGR5 signaling is poorly understood. Results: TGR5 does not interact with β-arrestins, internalize, or desensitize, but signals from plasma membrane rafts. Conclusion: TGR5 transmits sustained signals close to the cell surface. Significance: Understanding TGR5 signaling will facilitate design of TGR5 agonists for metabolic, inflammatory, and digestive disorders.

AB - Background: The TGR5 bile acid receptor controls energy balance, inflammation, and digestion, but TGR5 signaling is poorly understood. Results: TGR5 does not interact with β-arrestins, internalize, or desensitize, but signals from plasma membrane rafts. Conclusion: TGR5 transmits sustained signals close to the cell surface. Significance: Understanding TGR5 signaling will facilitate design of TGR5 agonists for metabolic, inflammatory, and digestive disorders.

UR - http://www.scopus.com/inward/record.url?scp=84881464516&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84881464516&partnerID=8YFLogxK

U2 - 10.1074/jbc.M113.455774

DO - 10.1074/jbc.M113.455774

M3 - Article

C2 - 23818521

AN - SCOPUS:84881464516

VL - 288

SP - 22942

EP - 22960

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

SN - 0021-9258

IS - 32

ER -