Abstract
We have refined the location of the Brn-3a genomic locus (POU4F1), using somatic cell hybrid analysis, to 13q21.→q22. Furthermore, we have shown that two YACs, known to contain the closest marker linked to neuronal ceroidlipofuscinosis (CLN5), also contains the Brn-3a gene. As one of these YACs is only 320 kb long, this localises POU4F1 within the critical region defining the CLN5 locus, and raises the possibility that POU4F1 is a candidate gene for CLN5.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 225-226 |
| Number of pages | 2 |
| Journal | Cytogenetic and Genome Research |
| Volume | 74 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jan 1 1996 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Molecular Biology
- Genetics
- Genetics(clinical)
Cite this
The Brn-3a transcription factor gene (POU4F1) maps close to the locus for the variant late infantile form of neuronal ceroid-lipofuscinosis. / Still, I. H.; Cowell, John Kenneth.
In: Cytogenetic and Genome Research, Vol. 74, No. 3, 01.01.1996, p. 225-226.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The Brn-3a transcription factor gene (POU4F1) maps close to the locus for the variant late infantile form of neuronal ceroid-lipofuscinosis
AU - Still, I. H.
AU - Cowell, John Kenneth
PY - 1996/1/1
Y1 - 1996/1/1
N2 - We have refined the location of the Brn-3a genomic locus (POU4F1), using somatic cell hybrid analysis, to 13q21.→q22. Furthermore, we have shown that two YACs, known to contain the closest marker linked to neuronal ceroidlipofuscinosis (CLN5), also contains the Brn-3a gene. As one of these YACs is only 320 kb long, this localises POU4F1 within the critical region defining the CLN5 locus, and raises the possibility that POU4F1 is a candidate gene for CLN5.
AB - We have refined the location of the Brn-3a genomic locus (POU4F1), using somatic cell hybrid analysis, to 13q21.→q22. Furthermore, we have shown that two YACs, known to contain the closest marker linked to neuronal ceroidlipofuscinosis (CLN5), also contains the Brn-3a gene. As one of these YACs is only 320 kb long, this localises POU4F1 within the critical region defining the CLN5 locus, and raises the possibility that POU4F1 is a candidate gene for CLN5.
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UR - http://www.scopus.com/inward/citedby.url?scp=0029842917&partnerID=8YFLogxK
U2 - 10.1159/000134422
DO - 10.1159/000134422
M3 - Article
C2 - 8941380
AN - SCOPUS:0029842917
VL - 74
SP - 225
EP - 226
JO - Cytogenetic and Genome Research
JF - Cytogenetic and Genome Research
SN - 1424-8581
IS - 3
ER -