TY - JOUR
T1 - The cachexia associated with Trypanosoma cruzi acute infection in mice is attenuated by anti‐TNF‐a, but not by anti‐IL‐6 or anti‐IFN‐7 antibodies
AU - TRUYENS, CARINE
AU - TORRICO, FAUSTINO
AU - ANGELO‐BARRIOS, ALCIRA
AU - LUCAS, RALF
AU - HEREMANS, HUBERTINE
AU - BAETSELIER, PATRICK DE
AU - CARLIER, YVES
PY - 1995/11
Y1 - 1995/11
N2 - BALB/c male mice acutely infected with Trypanosoma cruzi underwent a severe weight loss (around 20%, from day 18 to 31 post‐infection), when compared to age‐matched uninfected animals. Though mice regained weight later, when blood parasites were hardly detectable, wasting extended over the chronic phase of infection. The onset and the magnitude of weight loss were related to the mouse susceptibility to infection, since they were respectively earlier and higher in male mice which will die than in surviving ones, in males than in females, and in BALB/c than in B6D2 [(C57B1/6 × DBA/2)F1], a mouse strain more resistant to infection. Fat weight of infected mice (male BALB/c) was reduced by 60 to 80%, whereas lean mass was unaffected and water content rose by 6 to 10% in acute and chronic infection. Haematocrit was also decreased by 15–16% in acute infection. Animals failed to compensate their energetic loss since their food intake remained similar to that of uninfected animals. Injections of neutralizing anti‐TNF‐α monoclonal antibody into infected male mice, during the first two weeks but not later in infection, significantly attenuated the weight loss. Early administration of anti‐IL‐6 or anti‐IFN‐γ MoAbs did not improve the mouse wasting. Taken together, these data show that TNFis a key agent of cachexia occurring in the acute T. cruzi infection in mice.
AB - BALB/c male mice acutely infected with Trypanosoma cruzi underwent a severe weight loss (around 20%, from day 18 to 31 post‐infection), when compared to age‐matched uninfected animals. Though mice regained weight later, when blood parasites were hardly detectable, wasting extended over the chronic phase of infection. The onset and the magnitude of weight loss were related to the mouse susceptibility to infection, since they were respectively earlier and higher in male mice which will die than in surviving ones, in males than in females, and in BALB/c than in B6D2 [(C57B1/6 × DBA/2)F1], a mouse strain more resistant to infection. Fat weight of infected mice (male BALB/c) was reduced by 60 to 80%, whereas lean mass was unaffected and water content rose by 6 to 10% in acute and chronic infection. Haematocrit was also decreased by 15–16% in acute infection. Animals failed to compensate their energetic loss since their food intake remained similar to that of uninfected animals. Injections of neutralizing anti‐TNF‐α monoclonal antibody into infected male mice, during the first two weeks but not later in infection, significantly attenuated the weight loss. Early administration of anti‐IL‐6 or anti‐IFN‐γ MoAbs did not improve the mouse wasting. Taken together, these data show that TNFis a key agent of cachexia occurring in the acute T. cruzi infection in mice.
KW - IFN‐γ
KW - T. cruzi
KW - anti‐cytokine monoclonal antibodies
KW - body composition
KW - cachexia
KW - interleukin‐6
KW - tumour necrosis factor
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U2 - 10.1111/j.1365-3024.1995.tb00999.x
DO - 10.1111/j.1365-3024.1995.tb00999.x
M3 - Article
C2 - 8817602
AN - SCOPUS:0029593387
SN - 0141-9838
VL - 17
SP - 561
EP - 568
JO - Parasite Immunology
JF - Parasite Immunology
IS - 11
ER -