The cachexia associated with Trypanosoma cruzi acute infection in mice is attenuated by anti‐TNF‐a, but not by anti‐IL‐6 or anti‐IFN‐7 antibodies

CARINE TRUYENS, FAUSTINO TORRICO, ALCIRA ANGELO‐BARRIOS, RALF LUCAS, HUBERTINE HEREMANS, PATRICK DE BAETSELIER, YVES CARLIER

Research output: Contribution to journalArticle

52 Scopus citations

Abstract

BALB/c male mice acutely infected with Trypanosoma cruzi underwent a severe weight loss (around 20%, from day 18 to 31 post‐infection), when compared to age‐matched uninfected animals. Though mice regained weight later, when blood parasites were hardly detectable, wasting extended over the chronic phase of infection. The onset and the magnitude of weight loss were related to the mouse susceptibility to infection, since they were respectively earlier and higher in male mice which will die than in surviving ones, in males than in females, and in BALB/c than in B6D2 [(C57B1/6 × DBA/2)F1], a mouse strain more resistant to infection. Fat weight of infected mice (male BALB/c) was reduced by 60 to 80%, whereas lean mass was unaffected and water content rose by 6 to 10% in acute and chronic infection. Haematocrit was also decreased by 15–16% in acute infection. Animals failed to compensate their energetic loss since their food intake remained similar to that of uninfected animals. Injections of neutralizing anti‐TNF‐α monoclonal antibody into infected male mice, during the first two weeks but not later in infection, significantly attenuated the weight loss. Early administration of anti‐IL‐6 or anti‐IFN‐γ MoAbs did not improve the mouse wasting. Taken together, these data show that TNFis a key agent of cachexia occurring in the acute T. cruzi infection in mice.

Original languageEnglish (US)
Pages (from-to)561-568
Number of pages8
JournalParasite Immunology
Volume17
Issue number11
DOIs
StatePublished - Jan 1 1995
Externally publishedYes

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Keywords

  • IFN‐γ
  • T. cruzi
  • anti‐cytokine monoclonal antibodies
  • body composition
  • cachexia
  • interleukin‐6
  • tumour necrosis factor

ASJC Scopus subject areas

  • Parasitology
  • Immunology

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