The characteristics of cognitive neuroscience tests in a schizophrenia cognition clinical trial: Psychometric properties and correlations with standard measures

Michael S. Kraus; James M. Gold; Deanna M. Barch; Trina M. Walker; Charlotte A. Chun; Robert W. Buchanan; John G. Csernansky; Donald C. Goff; Michael F. Green; L. Fredrik Jarskog; Daniel C. Javitt; David Kimhy; Jeffrey A. Lieberman; Joseph P. McEvoy; Raquelle I. Mesholam-Gately; Larry J. Seidman; M. Patricia Ball; Robert S. Kern; Robert P. McMahon; James Robinson; Stephen R. Marder; Richard S.E. Keefe

doi:10.1016/j.scog.2019.100161

The characteristics of cognitive neuroscience tests in a schizophrenia cognition clinical trial: Psychometric properties and correlations with standard measures

Michael S. Kraus, James M. Gold, Deanna M. Barch, Trina M. Walker, Charlotte A. Chun, Robert W. Buchanan, John G. Csernansky, Donald C. Goff, Michael F. Green, L. Fredrik Jarskog, Daniel C. Javitt, David Kimhy, Jeffrey A. Lieberman, Joseph P. McEvoy, Raquelle I. Mesholam-Gately, Larry J. Seidman, M. Patricia Ball, Robert S. Kern, Robert P. McMahon, James RobinsonStephen R. Marder, Richard S.E. Keefe

Research output: Contribution to journal › Article › peer-review

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Abstract

In comparison to batteries of standard neuropsychological tests, cognitive neuroscience tests may offer a more specific assessment of discrete neurobiological processes that may be aberrant in schizophrenia. However, more information regarding psychometric properties and correlations with standard neuropsychological tests and functional measures is warranted to establish their validity as treatment outcome measures. The N-back and AX-Continuous Performance Task (AX-CPT) are two promising cognitive neuroscience tests designed to measure specific components of working memory and contextual processing respectively. In the current study, we report the psychometric properties of multiple outcome measures from these two tests as well as their correlations with standard neuropsychological measures and functional capacity measures. The results suggest that while the AX-CPT and N-back display favorable psychometric properties, they do not exhibit greater sensitivity or specificity with functional measures than standard neurocognitive tests.

Original language	English (US)
Article number	100161
Journal	Schizophrenia Research: Cognition
Volume	19
DOIs	https://doi.org/10.1016/j.scog.2019.100161
State	Published - Mar 2020
Externally published	Yes

ASJC Scopus subject areas

Cognitive Neuroscience
Psychiatry and Mental health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.scog.2019.100161

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Kraus, M. S., Gold, J. M., Barch, D. M., Walker, T. M., Chun, C. A., Buchanan, R. W., Csernansky, J. G., Goff, D. C., Green, M. F., Jarskog, L. F., Javitt, D. C., Kimhy, D., Lieberman, J. A., McEvoy, J. P., Mesholam-Gately, R. I., Seidman, L. J., Ball, M. P., Kern, R. S., McMahon, R. P., ... Keefe, R. S. E. (2020). The characteristics of cognitive neuroscience tests in a schizophrenia cognition clinical trial: Psychometric properties and correlations with standard measures. Schizophrenia Research: Cognition, 19, Article 100161. https://doi.org/10.1016/j.scog.2019.100161

Kraus, MS, Gold, JM, Barch, DM, Walker, TM, Chun, CA, Buchanan, RW, Csernansky, JG, Goff, DC, Green, MF, Jarskog, LF, Javitt, DC, Kimhy, D, Lieberman, JA, McEvoy, JP, Mesholam-Gately, RI, Seidman, LJ, Ball, MP, Kern, RS, McMahon, RP, Robinson, J, Marder, SR & Keefe, RSE 2020, 'The characteristics of cognitive neuroscience tests in a schizophrenia cognition clinical trial: Psychometric properties and correlations with standard measures', Schizophrenia Research: Cognition, vol. 19, 100161. https://doi.org/10.1016/j.scog.2019.100161

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abstract = "In comparison to batteries of standard neuropsychological tests, cognitive neuroscience tests may offer a more specific assessment of discrete neurobiological processes that may be aberrant in schizophrenia. However, more information regarding psychometric properties and correlations with standard neuropsychological tests and functional measures is warranted to establish their validity as treatment outcome measures. The N-back and AX-Continuous Performance Task (AX-CPT) are two promising cognitive neuroscience tests designed to measure specific components of working memory and contextual processing respectively. In the current study, we report the psychometric properties of multiple outcome measures from these two tests as well as their correlations with standard neuropsychological measures and functional capacity measures. The results suggest that while the AX-CPT and N-back display favorable psychometric properties, they do not exhibit greater sensitivity or specificity with functional measures than standard neurocognitive tests.",

author = "Kraus, {Michael S.} and Gold, {James M.} and Barch, {Deanna M.} and Walker, {Trina M.} and Chun, {Charlotte A.} and Buchanan, {Robert W.} and Csernansky, {John G.} and Goff, {Donald C.} and Green, {Michael F.} and Jarskog, {L. Fredrik} and Javitt, {Daniel C.} and David Kimhy and Lieberman, {Jeffrey A.} and McEvoy, {Joseph P.} and Mesholam-Gately, {Raquelle I.} and Seidman, {Larry J.} and Ball, {M. Patricia} and Kern, {Robert S.} and McMahon, {Robert P.} and James Robinson and Marder, {Stephen R.} and Keefe, {Richard S.E.}",

note = "Publisher Copyright: {\textcopyright} 2019",

year = "2020",

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doi = "10.1016/j.scog.2019.100161",

language = "English (US)",

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AU - Kraus, Michael S.

AU - Gold, James M.

AU - Barch, Deanna M.

AU - Walker, Trina M.

AU - Chun, Charlotte A.

AU - Buchanan, Robert W.

AU - Csernansky, John G.

AU - Goff, Donald C.

AU - Green, Michael F.

AU - Jarskog, L. Fredrik

AU - Javitt, Daniel C.

AU - Kimhy, David

AU - Lieberman, Jeffrey A.

AU - McEvoy, Joseph P.

AU - Mesholam-Gately, Raquelle I.

AU - Seidman, Larry J.

AU - Ball, M. Patricia

AU - Kern, Robert S.

AU - McMahon, Robert P.

AU - Robinson, James

AU - Marder, Stephen R.

AU - Keefe, Richard S.E.

PY - 2020/3

Y1 - 2020/3

N2 - In comparison to batteries of standard neuropsychological tests, cognitive neuroscience tests may offer a more specific assessment of discrete neurobiological processes that may be aberrant in schizophrenia. However, more information regarding psychometric properties and correlations with standard neuropsychological tests and functional measures is warranted to establish their validity as treatment outcome measures. The N-back and AX-Continuous Performance Task (AX-CPT) are two promising cognitive neuroscience tests designed to measure specific components of working memory and contextual processing respectively. In the current study, we report the psychometric properties of multiple outcome measures from these two tests as well as their correlations with standard neuropsychological measures and functional capacity measures. The results suggest that while the AX-CPT and N-back display favorable psychometric properties, they do not exhibit greater sensitivity or specificity with functional measures than standard neurocognitive tests.

AB - In comparison to batteries of standard neuropsychological tests, cognitive neuroscience tests may offer a more specific assessment of discrete neurobiological processes that may be aberrant in schizophrenia. However, more information regarding psychometric properties and correlations with standard neuropsychological tests and functional measures is warranted to establish their validity as treatment outcome measures. The N-back and AX-Continuous Performance Task (AX-CPT) are two promising cognitive neuroscience tests designed to measure specific components of working memory and contextual processing respectively. In the current study, we report the psychometric properties of multiple outcome measures from these two tests as well as their correlations with standard neuropsychological measures and functional capacity measures. The results suggest that while the AX-CPT and N-back display favorable psychometric properties, they do not exhibit greater sensitivity or specificity with functional measures than standard neurocognitive tests.

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The characteristics of cognitive neuroscience tests in a schizophrenia cognition clinical trial: Psychometric properties and correlations with standard measures

Abstract

ASJC Scopus subject areas

UN SDGs

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