The characterization of cell line CRL-2335 as a basal-like breast carcinoma model

L. A. Hill Neves, Lishann Ingram, Melissa B. Davis

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Basal-like breast cancer has been reported to be the most aggressive and deadly carcinoma sub-type. Patients diagnosed with this subtype have a less than 50% five-year survival. In addition, many studies have reported that this sub-type is more prevalent in specific ethnic groups and is believed to be a key factor that drives certain ethnic disparities in mortality. In order to effectively study this sub-type and determine unique gene expression and biochemical pathways which sustain this cancer's growth, we sought to identify human breast cancer cell lines that represent a model for the basal-like subtype. Here, we report our findings which indicate the African American cell line CRL-2335 is a true representative of basal-like breast carcinoma.

Original languageEnglish (US)
Pages (from-to)67-72
Number of pages6
JournalBreast Cancer: Basic and Clinical Research
Volume5
Issue number1
DOIs
StatePublished - 2011

Keywords

  • Basal-like breast cancer
  • Cell line model
  • Triple negative breast cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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