Abstract
Basal-like breast cancer has been reported to be the most aggressive and deadly carcinoma sub-type. Patients diagnosed with this subtype have a less than 50% five-year survival. In addition, many studies have reported that this sub-type is more prevalent in specific ethnic groups and is believed to be a key factor that drives certain ethnic disparities in mortality. In order to effectively study this sub-type and determine unique gene expression and biochemical pathways which sustain this cancer's growth, we sought to identify human breast cancer cell lines that represent a model for the basal-like subtype. Here, we report our findings which indicate the African American cell line CRL-2335 is a true representative of basal-like breast carcinoma.
Original language | English (US) |
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Pages (from-to) | 67-72 |
Number of pages | 6 |
Journal | Breast Cancer: Basic and Clinical Research |
Volume | 5 |
Issue number | 1 |
DOIs | |
State | Published - 2011 |
Externally published | Yes |
Keywords
- Basal-like breast cancer
- Cell line model
- Triple negative breast cancer
ASJC Scopus subject areas
- Oncology
- Cancer Research