The class I MHC gene family in mice

Andrew Mellor

Research output: Contribution to journalReview article

10 Citations (Scopus)

Abstract

Molecular genetic analysis of the murine MHC reveals that the class I gene family is far larger than expected from immunogenetic analysis of class I polypeptides. Of approximately 30 class I genes present in mouse DNA most are located telomeric to the H-2 regions in the adjacent Qa and Tla regions. Although it is not yet known how many class I genes from the Qa and Tla regions are expressed to produce class I polypeptides, evidence is accumulating that at least some of these genes encode polypeptides whose structure, and presumably function, is very different from the H-2K, D and L class I polypeptides. Here, Andrew Mellor reviews the structural data which reveals the unexpeted complexity of the class I gene family, particularly in the Qa and Tla regions. He discusses how molecular cloning and analysis of these genes are providing evidence that class I genes in these regions encode polypeptides which are highly homologous to the classical H-2 antigens but which are structurally and functionally quite distinct from them.

Original languageEnglish (US)
Pages (from-to)19-24
Number of pages6
JournalImmunology Today
Volume7
Issue number1
DOIs
StatePublished - Jan 1 1986

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MHC Class I Genes
Peptides
H-2 Antigens
Immunogenetics
Molecular Cloning
Genes
Molecular Biology
DNA

ASJC Scopus subject areas

  • Immunology

Cite this

The class I MHC gene family in mice. / Mellor, Andrew.

In: Immunology Today, Vol. 7, No. 1, 01.01.1986, p. 19-24.

Research output: Contribution to journalReview article

Mellor, Andrew. / The class I MHC gene family in mice. In: Immunology Today. 1986 ; Vol. 7, No. 1. pp. 19-24.
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