The cochaperone SGTA (small glutamine-rich tetratricopeptide repeat-containing protein alpha) demonstrates regulatory specificity for the androgen, glucocorticoid, and progesterone receptors

Atanu Paul, Yenni A. Garcia, Bettina Zierer, Chaitanya Patwardhan, Omar Gutierrez, Zacariah Hildenbrand, Diondra C. Harris, Heather A. Balsiger, Jeffrey C. Sivils, Jill L. Johnson, Johannes Buchner, Ahmed Chadli, Marc B. Cox

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background: Cochaperones are important for the folding and activation of steroid hormone receptors. Results: The androgen receptor-associated cochaperone SGTA binds both Hsp70 and Hsp90 and regulates progesterone and glucocorticoid receptors. Conclusion: SGTA is a receptor-specific cochaperone that regulates distinct steps in the receptor chaperoning cycle. Significance: SGTA is a relevant factor in diseases that depend on androgens, progestins and/or glucocorticoids.

Original languageEnglish (US)
Pages (from-to)15297-15308
Number of pages12
JournalJournal of Biological Chemistry
Volume289
Issue number22
DOIs
StatePublished - May 30 2014

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Steroid hormones
Steroid Receptors
Glucocorticoid Receptors
Androgen Receptors
Progestins
Progesterone Receptors
Glutamine
Glucocorticoids
Androgens
Chemical activation
Hormones
Proteins

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

The cochaperone SGTA (small glutamine-rich tetratricopeptide repeat-containing protein alpha) demonstrates regulatory specificity for the androgen, glucocorticoid, and progesterone receptors. / Paul, Atanu; Garcia, Yenni A.; Zierer, Bettina; Patwardhan, Chaitanya; Gutierrez, Omar; Hildenbrand, Zacariah; Harris, Diondra C.; Balsiger, Heather A.; Sivils, Jeffrey C.; Johnson, Jill L.; Buchner, Johannes; Chadli, Ahmed; Cox, Marc B.

In: Journal of Biological Chemistry, Vol. 289, No. 22, 30.05.2014, p. 15297-15308.

Research output: Contribution to journalArticle

Paul, A, Garcia, YA, Zierer, B, Patwardhan, C, Gutierrez, O, Hildenbrand, Z, Harris, DC, Balsiger, HA, Sivils, JC, Johnson, JL, Buchner, J, Chadli, A & Cox, MB 2014, 'The cochaperone SGTA (small glutamine-rich tetratricopeptide repeat-containing protein alpha) demonstrates regulatory specificity for the androgen, glucocorticoid, and progesterone receptors', Journal of Biological Chemistry, vol. 289, no. 22, pp. 15297-15308. https://doi.org/10.1074/jbc.M113.535229
Paul, Atanu ; Garcia, Yenni A. ; Zierer, Bettina ; Patwardhan, Chaitanya ; Gutierrez, Omar ; Hildenbrand, Zacariah ; Harris, Diondra C. ; Balsiger, Heather A. ; Sivils, Jeffrey C. ; Johnson, Jill L. ; Buchner, Johannes ; Chadli, Ahmed ; Cox, Marc B. / The cochaperone SGTA (small glutamine-rich tetratricopeptide repeat-containing protein alpha) demonstrates regulatory specificity for the androgen, glucocorticoid, and progesterone receptors. In: Journal of Biological Chemistry. 2014 ; Vol. 289, No. 22. pp. 15297-15308.
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AU - Chadli, Ahmed

AU - Cox, Marc B.

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