The cochaperone SGTA (small glutamine-rich tetratricopeptide repeat-containing protein alpha) demonstrates regulatory specificity for the androgen, glucocorticoid, and progesterone receptors

Atanu Paul; Yenni A. Garcia; Bettina Zierer; Chaitanya Patwardhan; Omar Gutierrez; Zacariah Hildenbrand; Diondra C. Harris; Heather A. Balsiger; Jeffrey C. Sivils; Jill L. Johnson; Johannes Buchner; Ahmed Chadli; Marc B. Cox

doi:10.1074/jbc.M113.535229

The cochaperone SGTA (small glutamine-rich tetratricopeptide repeat-containing protein alpha) demonstrates regulatory specificity for the androgen, glucocorticoid, and progesterone receptors

Atanu Paul, Yenni A. Garcia, Bettina Zierer, Chaitanya Patwardhan, Omar Gutierrez, Zacariah Hildenbrand, Diondra C. Harris, Heather A. Balsiger, Jeffrey C. Sivils, Jill L. Johnson, Johannes Buchner, Ahmed Chadli, Marc B. Cox

Biochemistry and Molecular Biology

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Background: Cochaperones are important for the folding and activation of steroid hormone receptors. Results: The androgen receptor-associated cochaperone SGTA binds both Hsp70 and Hsp90 and regulates progesterone and glucocorticoid receptors. Conclusion: SGTA is a receptor-specific cochaperone that regulates distinct steps in the receptor chaperoning cycle. Significance: SGTA is a relevant factor in diseases that depend on androgens, progestins and/or glucocorticoids.

Original language	English (US)
Pages (from-to)	15297-15308
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	289
Issue number	22
DOIs	https://doi.org/10.1074/jbc.M113.535229
State	Published - May 30 2014

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1074/jbc.M113.535229

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Paul, A., Garcia, Y. A., Zierer, B., Patwardhan, C., Gutierrez, O., Hildenbrand, Z., Harris, D. C., Balsiger, H. A., Sivils, J. C., Johnson, J. L., Buchner, J., Chadli, A., & Cox, M. B. (2014). The cochaperone SGTA (small glutamine-rich tetratricopeptide repeat-containing protein alpha) demonstrates regulatory specificity for the androgen, glucocorticoid, and progesterone receptors. Journal of Biological Chemistry, 289(22), 15297-15308. https://doi.org/10.1074/jbc.M113.535229

The cochaperone SGTA (small glutamine-rich tetratricopeptide repeat-containing protein alpha) demonstrates regulatory specificity for the androgen, glucocorticoid, and progesterone receptors. / Paul, Atanu; Garcia, Yenni A.; Zierer, Bettina et al.
In: Journal of Biological Chemistry, Vol. 289, No. 22, 30.05.2014, p. 15297-15308.

Research output: Contribution to journal › Article › peer-review

Paul, A, Garcia, YA, Zierer, B, Patwardhan, C, Gutierrez, O, Hildenbrand, Z, Harris, DC, Balsiger, HA, Sivils, JC, Johnson, JL, Buchner, J, Chadli, A & Cox, MB 2014, 'The cochaperone SGTA (small glutamine-rich tetratricopeptide repeat-containing protein alpha) demonstrates regulatory specificity for the androgen, glucocorticoid, and progesterone receptors', Journal of Biological Chemistry, vol. 289, no. 22, pp. 15297-15308. https://doi.org/10.1074/jbc.M113.535229

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abstract = "Background: Cochaperones are important for the folding and activation of steroid hormone receptors. Results: The androgen receptor-associated cochaperone SGTA binds both Hsp70 and Hsp90 and regulates progesterone and glucocorticoid receptors. Conclusion: SGTA is a receptor-specific cochaperone that regulates distinct steps in the receptor chaperoning cycle. Significance: SGTA is a relevant factor in diseases that depend on androgens, progestins and/or glucocorticoids.",

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AU - Patwardhan, Chaitanya

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AU - Hildenbrand, Zacariah

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AU - Sivils, Jeffrey C.

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AU - Buchner, Johannes

AU - Chadli, Ahmed

AU - Cox, Marc B.

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The cochaperone SGTA (small glutamine-rich tetratricopeptide repeat-containing protein alpha) demonstrates regulatory specificity for the androgen, glucocorticoid, and progesterone receptors

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