The cochaperone SGTA (small glutamine-rich tetratricopeptide repeat-containing protein alpha) demonstrates regulatory specificity for the androgen, glucocorticoid, and progesterone receptors

Atanu Paul, Yenni A. Garcia, Bettina Zierer, Chaitanya Patwardhan, Omar Gutierrez, Zacariah Hildenbrand, Diondra C. Harris, Heather A. Balsiger, Jeffrey C. Sivils, Jill L. Johnson, Johannes Buchner, Ahmed Chadli, Marc B. Cox

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Background: Cochaperones are important for the folding and activation of steroid hormone receptors. Results: The androgen receptor-associated cochaperone SGTA binds both Hsp70 and Hsp90 and regulates progesterone and glucocorticoid receptors. Conclusion: SGTA is a receptor-specific cochaperone that regulates distinct steps in the receptor chaperoning cycle. Significance: SGTA is a relevant factor in diseases that depend on androgens, progestins and/or glucocorticoids.

Original languageEnglish (US)
Pages (from-to)15297-15308
Number of pages12
JournalJournal of Biological Chemistry
Volume289
Issue number22
DOIs
StatePublished - May 30 2014

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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    Paul, A., Garcia, Y. A., Zierer, B., Patwardhan, C., Gutierrez, O., Hildenbrand, Z., Harris, D. C., Balsiger, H. A., Sivils, J. C., Johnson, J. L., Buchner, J., Chadli, A., & Cox, M. B. (2014). The cochaperone SGTA (small glutamine-rich tetratricopeptide repeat-containing protein alpha) demonstrates regulatory specificity for the androgen, glucocorticoid, and progesterone receptors. Journal of Biological Chemistry, 289(22), 15297-15308. https://doi.org/10.1074/jbc.M113.535229