The contribution of Toll-like receptors to placental inflammation in diet-induced maternal obesity

Jennifer A. Thompson, Trevor A. Hardigan, Maria Alicia Carrillo-Sepulveda, James D. Mintz, Adviye Ergul, Michael P. Diamond, R. Clinton Webb

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Toll-like receptor (TLR)-regulated protein kinases and inflammatory cytokines were activated in fetal vascular smooth muscle cells (VSMC) treated with palmitate. Tumor necrosis factor (TNFα) and interleukin-6 (IL6) were increased and correlated with expression of TLRs in the labyrinth placentae of high fat (HF)-fed rats with increased plasma lipids and visceral adiposity. Thus, local induction of TLR signaling via saturated fatty acids (SFA) may in part contribute to placental inflammation in diet-induced maternal obesity.

Original languageEnglish (US)
Pages (from-to)1204-1206
Number of pages3
JournalPlacenta
Volume36
Issue number10
DOIs
StateE-pub ahead of print - Aug 6 2015

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Keywords

  • Maternal obesity
  • Placental inflammation
  • Toll-like receptors

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology
  • Developmental Biology

Cite this

Thompson, J. A., Hardigan, T. A., Carrillo-Sepulveda, M. A., Mintz, J. D., Ergul, A., Diamond, M. P., & Webb, R. C. (2015). The contribution of Toll-like receptors to placental inflammation in diet-induced maternal obesity. Placenta, 36(10), 1204-1206. https://doi.org/10.1016/j.placenta.2015.07.132