The contribution of Toll-like receptors to placental inflammation in diet-induced maternal obesity

Jennifer A. Thompson, Trevor A. Hardigan, Maria Alicia Carrillo-Sepulveda, James D. Mintz, Adviye Ergul, Michael P. Diamond, R. Clinton Webb

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Toll-like receptor (TLR)-regulated protein kinases and inflammatory cytokines were activated in fetal vascular smooth muscle cells (VSMC) treated with palmitate. Tumor necrosis factor (TNFα) and interleukin-6 (IL6) were increased and correlated with expression of TLRs in the labyrinth placentae of high fat (HF)-fed rats with increased plasma lipids and visceral adiposity. Thus, local induction of TLR signaling via saturated fatty acids (SFA) may in part contribute to placental inflammation in diet-induced maternal obesity.

Original languageEnglish (US)
Pages (from-to)1204-1206
Number of pages3
JournalPlacenta
Volume36
Issue number10
DOIs
StateE-pub ahead of print - Aug 6 2015

Keywords

  • Maternal obesity
  • Placental inflammation
  • Toll-like receptors

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology
  • Developmental Biology

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