Abstract
Toll-like receptor (TLR)-regulated protein kinases and inflammatory cytokines were activated in fetal vascular smooth muscle cells (VSMC) treated with palmitate. Tumor necrosis factor (TNFα) and interleukin-6 (IL6) were increased and correlated with expression of TLRs in the labyrinth placentae of high fat (HF)-fed rats with increased plasma lipids and visceral adiposity. Thus, local induction of TLR signaling via saturated fatty acids (SFA) may in part contribute to placental inflammation in diet-induced maternal obesity.
Original language | English (US) |
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Pages (from-to) | 1204-1206 |
Number of pages | 3 |
Journal | Placenta |
Volume | 36 |
Issue number | 10 |
DOIs | |
State | E-pub ahead of print - Aug 6 2015 |
Keywords
- Maternal obesity
- Placental inflammation
- Toll-like receptors
ASJC Scopus subject areas
- Reproductive Medicine
- Obstetrics and Gynecology
- Developmental Biology