The contribution of Toll-like receptors to placental inflammation in diet-induced maternal obesity

Jennifer A. Thompson, Trevor A. Hardigan, Maria Alicia Carrillo-Sepulveda, James D. Mintz, Adviye Ergul, Michael Peter Diamond, R Clinton Webb

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Toll-like receptor (TLR)-regulated protein kinases and inflammatory cytokines were activated in fetal vascular smooth muscle cells (VSMC) treated with palmitate. Tumor necrosis factor (TNFα) and interleukin-6 (IL6) were increased and correlated with expression of TLRs in the labyrinth placentae of high fat (HF)-fed rats with increased plasma lipids and visceral adiposity. Thus, local induction of TLR signaling via saturated fatty acids (SFA) may in part contribute to placental inflammation in diet-induced maternal obesity.

Original languageEnglish (US)
Pages (from-to)1204-1206
Number of pages3
JournalPlacenta
Volume36
Issue number10
DOIs
StateE-pub ahead of print - Aug 6 2015

Fingerprint

Toll-Like Receptors
Obesity
Mothers
Diet
Inflammation
Palmitates
Adiposity
Inner Ear
Vascular Smooth Muscle
Protein Kinases
Placenta
Smooth Muscle Myocytes
Interleukin-6
Fatty Acids
Tumor Necrosis Factor-alpha
Fats
Cytokines
Lipids

Keywords

  • Maternal obesity
  • Placental inflammation
  • Toll-like receptors

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology
  • Developmental Biology

Cite this

The contribution of Toll-like receptors to placental inflammation in diet-induced maternal obesity. / Thompson, Jennifer A.; Hardigan, Trevor A.; Carrillo-Sepulveda, Maria Alicia; Mintz, James D.; Ergul, Adviye; Diamond, Michael Peter; Webb, R Clinton.

In: Placenta, Vol. 36, No. 10, 06.08.2015, p. 1204-1206.

Research output: Contribution to journalArticle

Thompson, Jennifer A. ; Hardigan, Trevor A. ; Carrillo-Sepulveda, Maria Alicia ; Mintz, James D. ; Ergul, Adviye ; Diamond, Michael Peter ; Webb, R Clinton. / The contribution of Toll-like receptors to placental inflammation in diet-induced maternal obesity. In: Placenta. 2015 ; Vol. 36, No. 10. pp. 1204-1206.
@article{57182a3cb4c54bcf8348ea00b8ff2d57,
title = "The contribution of Toll-like receptors to placental inflammation in diet-induced maternal obesity",
abstract = "Toll-like receptor (TLR)-regulated protein kinases and inflammatory cytokines were activated in fetal vascular smooth muscle cells (VSMC) treated with palmitate. Tumor necrosis factor (TNFα) and interleukin-6 (IL6) were increased and correlated with expression of TLRs in the labyrinth placentae of high fat (HF)-fed rats with increased plasma lipids and visceral adiposity. Thus, local induction of TLR signaling via saturated fatty acids (SFA) may in part contribute to placental inflammation in diet-induced maternal obesity.",
keywords = "Maternal obesity, Placental inflammation, Toll-like receptors",
author = "Thompson, {Jennifer A.} and Hardigan, {Trevor A.} and Carrillo-Sepulveda, {Maria Alicia} and Mintz, {James D.} and Adviye Ergul and Diamond, {Michael Peter} and Webb, {R Clinton}",
year = "2015",
month = "8",
day = "6",
doi = "10.1016/j.placenta.2015.07.132",
language = "English (US)",
volume = "36",
pages = "1204--1206",
journal = "Placenta",
issn = "0143-4004",
publisher = "W.B. Saunders Ltd",
number = "10",

}

TY - JOUR

T1 - The contribution of Toll-like receptors to placental inflammation in diet-induced maternal obesity

AU - Thompson, Jennifer A.

AU - Hardigan, Trevor A.

AU - Carrillo-Sepulveda, Maria Alicia

AU - Mintz, James D.

AU - Ergul, Adviye

AU - Diamond, Michael Peter

AU - Webb, R Clinton

PY - 2015/8/6

Y1 - 2015/8/6

N2 - Toll-like receptor (TLR)-regulated protein kinases and inflammatory cytokines were activated in fetal vascular smooth muscle cells (VSMC) treated with palmitate. Tumor necrosis factor (TNFα) and interleukin-6 (IL6) were increased and correlated with expression of TLRs in the labyrinth placentae of high fat (HF)-fed rats with increased plasma lipids and visceral adiposity. Thus, local induction of TLR signaling via saturated fatty acids (SFA) may in part contribute to placental inflammation in diet-induced maternal obesity.

AB - Toll-like receptor (TLR)-regulated protein kinases and inflammatory cytokines were activated in fetal vascular smooth muscle cells (VSMC) treated with palmitate. Tumor necrosis factor (TNFα) and interleukin-6 (IL6) were increased and correlated with expression of TLRs in the labyrinth placentae of high fat (HF)-fed rats with increased plasma lipids and visceral adiposity. Thus, local induction of TLR signaling via saturated fatty acids (SFA) may in part contribute to placental inflammation in diet-induced maternal obesity.

KW - Maternal obesity

KW - Placental inflammation

KW - Toll-like receptors

UR - http://www.scopus.com/inward/record.url?scp=84944279916&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84944279916&partnerID=8YFLogxK

U2 - 10.1016/j.placenta.2015.07.132

DO - 10.1016/j.placenta.2015.07.132

M3 - Article

VL - 36

SP - 1204

EP - 1206

JO - Placenta

JF - Placenta

SN - 0143-4004

IS - 10

ER -