The correlation of matrix metalloproteinase 9-to-Albumin ratio in wound fluid with postsurgical complications after body contouring

Kevin W. Sexton, Marcia Spear, Alonda C. Pollins, Chenai Nettey, Joseph Angelo Greco, R. Bruce Shack, Kevin F. Hagan, Lillian B. Nanney

Research output: Contribution to journalArticle

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Abstract

Background: The authors' earlier retrospective report of surgical complications after abdominal contouring surgery provided evidence that post-bariatric surgery patients are at increased risk of developing wound complications compared with a normal population. This prospective pilot study was designed as a comparative analysis of both surgical and wound healing characteristics between massive weight loss and normal patients who present for abdominal contouring surgery. Methods: Excisional wounds were created and polytetrafluoroethylene tubing was inserted during the preoperative period for later harvesting in patients undergoing abdominal contouring following Roux-en-Y gastric bypass for weight loss (n = 16) or abdominoplasty (n = 17). Wound fluids were sequentially collected from drains and subjected to matrix metalloproteinase (MMP) analysis. Standard postsurgical complications were documented. Results: Surgical complications were more common in weight loss patients (47 percent) than in control patients (25 percent). MMP analyses showed that MMP-9 levels remained significantly elevated at postoperative day 4 in patients who subsequently experienced complications in either the weight loss group (p = 0.02) or the control group (p = 0.03). Other parameters showed no significant differences between massive weight loss patients and controls. Conclusions: Although many markers were examined, the ratio of MMP-9 to albumin was the only predictor of postsurgical complications in any group. This lends further support to growing evidence that MMP-9 may be a useful biomarker of postsurgical complications. This pilot work showed no causal factors that explain the higher rates of postsurgical complications in the post- bariatric surgery patient population.

Original languageEnglish (US)
Pages (from-to)530e-538e
JournalPlastic and reconstructive surgery
Volume134
Issue number4
DOIs
StatePublished - Jan 1 2014

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Matrix Metalloproteinase 9
Albumins
Wounds and Injuries
Weight Loss
Bariatric Surgery
Matrix Metalloproteinases
Abdominoplasty
Preoperative Period
Gastric Bypass
Polytetrafluoroethylene
Wound Healing
Population
Biomarkers
Prospective Studies
Control Groups

ASJC Scopus subject areas

  • Surgery

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The correlation of matrix metalloproteinase 9-to-Albumin ratio in wound fluid with postsurgical complications after body contouring. / Sexton, Kevin W.; Spear, Marcia; Pollins, Alonda C.; Nettey, Chenai; Greco, Joseph Angelo; Shack, R. Bruce; Hagan, Kevin F.; Nanney, Lillian B.

In: Plastic and reconstructive surgery, Vol. 134, No. 4, 01.01.2014, p. 530e-538e.

Research output: Contribution to journalArticle

Sexton, Kevin W. ; Spear, Marcia ; Pollins, Alonda C. ; Nettey, Chenai ; Greco, Joseph Angelo ; Shack, R. Bruce ; Hagan, Kevin F. ; Nanney, Lillian B. / The correlation of matrix metalloproteinase 9-to-Albumin ratio in wound fluid with postsurgical complications after body contouring. In: Plastic and reconstructive surgery. 2014 ; Vol. 134, No. 4. pp. 530e-538e.
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AU - Greco, Joseph Angelo

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