The diagnostic value of a brief GnRH analogue stimulation test in girls with central precocious puberty

A single 30-minute post-stimulation LH sample is adequate

Christopher P. Houk, Allen R. Kunselman, Peter A. Lee

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

To ascertain the diagnostic value of GnRHa stimulation testing in girls with CPP, single sample 30 minute post-stimulated gonadotropin levels were compared between girls with CPP and prepubertal girls. Serum LH and FSH concentrations were assayed using two third generation gonadotropin assays. Clinical data were reviewed to establish the diagnosis of CPP. GnRHa stimulation testing with one LH measurement obtained 30 minutes after stimulation is adequate for evaluating girls with CPP and as reliable as GnRH stimulation testing.

Original languageEnglish (US)
Pages (from-to)1113-1118
Number of pages6
JournalJournal of Pediatric Endocrinology and Metabolism
Volume21
Issue number12
DOIs
StatePublished - Jan 1 2008
Externally publishedYes

Fingerprint

Gonadotropin-Releasing Hormone
Gonadotropins
3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid
Central Precocious Puberty
Serum

Keywords

  • Central precocious puberty
  • GnRH analogue testing
  • Luteinizing hormone

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

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AB - To ascertain the diagnostic value of GnRHa stimulation testing in girls with CPP, single sample 30 minute post-stimulated gonadotropin levels were compared between girls with CPP and prepubertal girls. Serum LH and FSH concentrations were assayed using two third generation gonadotropin assays. Clinical data were reviewed to establish the diagnosis of CPP. GnRHa stimulation testing with one LH measurement obtained 30 minutes after stimulation is adequate for evaluating girls with CPP and as reliable as GnRH stimulation testing.

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