The effect of mercuric acetate on selected enzymes of maternal and fetal hamsters at different gestational ages

Warren B. Karp, Thomas F Gale, S. B. Subramanyam, Robert H. DuRant

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

This study establishes levels of activity of glucose-6-phosphate dehydrogenase (G6PD), glycogen phosphorylase (GP), and cytochrome c oxidase (cyt c ox) in maternal, placental, and fetal tissues at Days 9, 12, and 15 in the 16-day gestation period of the hamster, and following a single dose of either 8 or 15 mg/kg mercuric acetate on the eighth gestational day. Mercury significantly elevated maternal kidney G6PD activity and decreased GP activity. The increase in kidney G6PD strongly correlated with observed urine and kidney abnormalities.

Original languageEnglish (US)
Pages (from-to)351-358
Number of pages8
JournalEnvironmental Research
Volume36
Issue number2
DOIs
StatePublished - Jan 1 1985

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Glucosephosphate Dehydrogenase
Cricetinae
Gestational Age
Glycogen Phosphorylase
acetate
glucose
Mothers
phosphate
enzyme
Kidney
Enzymes
Electron Transport Complex IV
abnormality
Mercury
pregnancy
urine
cytochrome
Fetus
Urine
Tissue

ASJC Scopus subject areas

  • Biochemistry
  • Environmental Science(all)

Cite this

The effect of mercuric acetate on selected enzymes of maternal and fetal hamsters at different gestational ages. / Karp, Warren B.; Gale, Thomas F; Subramanyam, S. B.; DuRant, Robert H.

In: Environmental Research, Vol. 36, No. 2, 01.01.1985, p. 351-358.

Research output: Contribution to journalArticle

Karp, Warren B. ; Gale, Thomas F ; Subramanyam, S. B. ; DuRant, Robert H. / The effect of mercuric acetate on selected enzymes of maternal and fetal hamsters at different gestational ages. In: Environmental Research. 1985 ; Vol. 36, No. 2. pp. 351-358.
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