The effect of photoinitiators on intracellular AKT signaling pathway in tissue engineering application

Leyuan Xu, Natasha Sheybani, W. Andrew Yeudall, Hu Yang

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Free-radical photopolymerization initiated by photoinitiators is an important method to make tissue engineering scaffolds. To advance understanding of photoinitiator cytocompatibility, we examined three photoinitiators including 2,2-dimethoxy-2-phenylacetophenone (DMPA), Irgacure 2959 (I-2959), and eosin Y photoinitiating system (EY) in terms of their effects on the viability of HN4 cells and expression levels of intracellular AKT and its phosphorylated form p-AKT. Our results show that the photoinitiators and their UV-exposed counterparts affect intracellular AKT signaling, which can be used in conjunction with cell viability for cytocompatibility assessment of photoinitiators.

Original languageEnglish (US)
Pages (from-to)250-255
Number of pages6
JournalBiomaterials Science
Volume3
Issue number2
DOIs
Publication statusPublished - Feb 1 2015
Externally publishedYes

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ASJC Scopus subject areas

  • Biomedical Engineering
  • Materials Science(all)

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