The effect of protein and urine on uropathogen adhesion to polymer substrata

Lesleyann Hawthorn, Gregor Reid

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


Uropathogenic adhesion was measured using a range of polymer materials with differing surface tension properties. Experiments were carried out in the presence of phosphate buffered saline (controls), Tamm Horsfall protein (THP), and human urine with quantitation by image analysis. The results showed that THP did not bind to the polymer materials and therefore did not act as a receptor surface for type 1 fimbriated Escherichia coli. However, the THP did interfere with adhesion by binding directly to these organisms as well as to Pseudomonas aeruginosa, Staphylococcus epidermidis, and, to a lesser extent, Proteus mirabilis. Incubation of the uropathogens in THP and urine resulted in altered adhesion profiles to polymer surfaces, with no single trend apparent. The results emphasize that fluid components, particularly proteins, and substratum surface tension influence bacterial adhesion to biomaterials.

Original languageEnglish (US)
Pages (from-to)1325-1332
Number of pages8
JournalJournal of Biomedical Materials Research
Issue number10
StatePublished - Oct 1990
Externally publishedYes

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering


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