The effect of regulation of high blood pressure on plasma endothelin-1 levels in blacks with hypertension

Sitki Ergul, Adviye Ergul, John A. Hudson, David Puett, Bobbye M. Wieman, Marcus D. Durham, David C. Parish

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Plasma concentrations of immunoreactive endothelin-1 (irET-1) are significantly elevated in blacks with hypertension. In the present study, we investigated the effect of the regulation of high blood pressure on plasma irET-1 levels in black hypertensive individuals. After the initial blood samples were collected from 20 black patients with uncontrolled high blood pressure (Day 1), an intensive antihypertensive treatment was initiated, and the blood pressure and plasma irET-1 levels were monitored on days 2, 8, and 22. When the high blood pressure was brought under control with commonly used antihypertensive medications, plasma irET-1 concentrations dropped dramatically, suggesting that ET-1 concentrations rise as a consequence of high blood pressure in this study group.

Original languageEnglish (US)
Pages (from-to)1381-1385
Number of pages5
JournalAmerican journal of hypertension
Volume11
Issue number11 I
DOIs
StatePublished - Nov 1 1998

Keywords

  • Antihypertensive treatment
  • Endothelin receptor antagonists
  • Endothelin-1
  • Essential hypertension
  • Race

ASJC Scopus subject areas

  • Internal Medicine

Fingerprint Dive into the research topics of 'The effect of regulation of high blood pressure on plasma endothelin-1 levels in blacks with hypertension'. Together they form a unique fingerprint.

  • Cite this

    Ergul, S., Ergul, A., Hudson, J. A., Puett, D., Wieman, B. M., Durham, M. D., & Parish, D. C. (1998). The effect of regulation of high blood pressure on plasma endothelin-1 levels in blacks with hypertension. American journal of hypertension, 11(11 I), 1381-1385. https://doi.org/10.1016/S0895-7061(98)00150-2