@article{3a2bd96e731a463cb513e5861e1dad74,
title = "The effect of transdermal nicotine on digital perfusion in reformed habitual smokers",
abstract = "The effects of transdermal nicotine-assisted smoking cessation on digital perfusion and health-related quality of life were assessed in 10 chronic smokers. Components of digital blood flow were evaluated by digital temperature and laser Doppler fluxmetry before, during, and after a standardized cold challenge. Nutritional flow was measured by vital capillaroscopy; a quantitative perfusion profile was obtained by laser Doppler perfusion imaging. A battery of validated measures were used to evaluate health-related quality of life. The microvascular response of smokers was evaluated before smoking cessation and at 2 and 7 days after smoking cessation and was compared with the response of nonsmoking controls. Results demonstrated that a (1) cutaneous microvascular perfusion was lower in smokers than nonsmokers, (2) the acute administration of transdermal nicotine did not decrease cutaneous perfusion, (3) smoking cessation and transdermal nicotine normalized digital microvascular perfusion by 7 days, and (4) transdermal nicotine and smoking cessation did not negatively impact health-related quality of life.",
author = "Fulcher, {S Marcus} and Koman, {L. A.} and Smith, {B. P.} and M. Holden and Smith, {T. L.}",
note = "Funding Information: Microsurgeons are frequently faced with the postoperative management of habitual cigarette smokers who have undergone emergency digital replantation or revascularization procedures. The negative effects of smoking on the microcirculation of replanted From the Department of Orthopaedic Surgery, Wake Forest University School of Medicine, Winston-Salem, NC. Supported in part by donation of Habitrol transdermal nicotine patches by Basel Pharmaceuticals, Ciba Geigy Corporation. Habitrol was provided without charge to the participants who completed the study protocol as part of a smoking cessation program. Received for publication November 21, 1997; accepted for publication March 31, 1998. The author or one or more of the authors have received or will receive benefits for personal or professional use from a commercial party related directly or indirectly to the subject of this article. Presented in part at the American Society for Surgery of the Hand, September 1997, Denver, CO. Reprint request: Thomas L. Smith, PhD, Department of Orthopaedic Surgery, Wake Forest University School of Medicine, Winston-Salem, NC 27157. Telephone: (910) 716-2930 Copyright 9 1998 by the American Society for Surgery of the Hand 0363-5023/98/23A05-000753.00/0",
year = "1998",
doi = "10.1016/s0363-5023(98)80152-4",
language = "English (US)",
volume = "23",
pages = "792--799",
journal = "Journal of Hand Surgery",
issn = "0363-5023",
publisher = "W.B. Saunders Ltd",
number = "5",
}