The effectiveness of inhalation isopropyl alcohol vs granisetron for the prevention of postoperative nausea and vomiting

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

We evaluated preemptive treatment for postoperative nausea and vomiting (PONV) with intravenous (IV) granisetron, 0.1 mg, intraoperatively as compared with the use of 70% inhalation isopropyl alcohol and a control group for the prevention of PONV. We randomly assigned 57 women, 18 to 50 years old, undergoing laparoscopic procedures to 1 of 3 groups: (1) inhalation of 70% isopropyl alcohol, (2) 0.1 mg granisetron IV, and (3) no prophylactic treatment control. Participants were asked to rate their nausea and vomiting preoperatively, on arrival to postanesthesia care unit (PACU), at discharge from PACU, 6 hours after extubation, and 24 hours after extubation and any occurrence of nausea and vomiting using the numeric rating scale (NRS), 0 to 10. Group 1 experienced more PONV episodes than groups 2 and 3 during the 6- to 24-hour postsurgical timeframe (P = .02). There were no significant differences among the 3 groups in demographics, first episode of PONV, total number of episodes in 24 hours, NRS rating at rescue, and anesthetic duration. PONV and menstrual cycle phase had no positive correlation (P > .05). History of smoking, PONV, and motion sickness had no significant difference against any measure of PONV (P >.05).

Original languageEnglish (US)
Pages (from-to)417-422
Number of pages6
JournalAANA Journal
Volume75
Issue number6
StatePublished - Dec 1 2007

Fingerprint

Granisetron
Postoperative Nausea and Vomiting
2-Propanol
Inhalation
Nausea
Vomiting
Motion Sickness
Menstrual Cycle
Anesthetics
Smoking
Demography
Control Groups
Therapeutics

Keywords

  • Granisetron
  • Inhalation isopropyl alcohol
  • Postoperative nausea and vomiting

ASJC Scopus subject areas

  • Medical–Surgical
  • Advanced and Specialized Nursing
  • Anesthesiology and Pain Medicine

Cite this

The effectiveness of inhalation isopropyl alcohol vs granisetron for the prevention of postoperative nausea and vomiting. / Teran, Lara; Hawkins, John Kenneth.

In: AANA Journal, Vol. 75, No. 6, 01.12.2007, p. 417-422.

Research output: Contribution to journalArticle

@article{c4674daa1e7e46c1a52346ecdcef94f3,
title = "The effectiveness of inhalation isopropyl alcohol vs granisetron for the prevention of postoperative nausea and vomiting",
abstract = "We evaluated preemptive treatment for postoperative nausea and vomiting (PONV) with intravenous (IV) granisetron, 0.1 mg, intraoperatively as compared with the use of 70{\%} inhalation isopropyl alcohol and a control group for the prevention of PONV. We randomly assigned 57 women, 18 to 50 years old, undergoing laparoscopic procedures to 1 of 3 groups: (1) inhalation of 70{\%} isopropyl alcohol, (2) 0.1 mg granisetron IV, and (3) no prophylactic treatment control. Participants were asked to rate their nausea and vomiting preoperatively, on arrival to postanesthesia care unit (PACU), at discharge from PACU, 6 hours after extubation, and 24 hours after extubation and any occurrence of nausea and vomiting using the numeric rating scale (NRS), 0 to 10. Group 1 experienced more PONV episodes than groups 2 and 3 during the 6- to 24-hour postsurgical timeframe (P = .02). There were no significant differences among the 3 groups in demographics, first episode of PONV, total number of episodes in 24 hours, NRS rating at rescue, and anesthetic duration. PONV and menstrual cycle phase had no positive correlation (P > .05). History of smoking, PONV, and motion sickness had no significant difference against any measure of PONV (P >.05).",
keywords = "Granisetron, Inhalation isopropyl alcohol, Postoperative nausea and vomiting",
author = "Lara Teran and Hawkins, {John Kenneth}",
year = "2007",
month = "12",
day = "1",
language = "English (US)",
volume = "75",
pages = "417--422",
journal = "AANA Journal",
issn = "0094-6354",
publisher = "AANA Publishing Inc.",
number = "6",

}

TY - JOUR

T1 - The effectiveness of inhalation isopropyl alcohol vs granisetron for the prevention of postoperative nausea and vomiting

AU - Teran, Lara

AU - Hawkins, John Kenneth

PY - 2007/12/1

Y1 - 2007/12/1

N2 - We evaluated preemptive treatment for postoperative nausea and vomiting (PONV) with intravenous (IV) granisetron, 0.1 mg, intraoperatively as compared with the use of 70% inhalation isopropyl alcohol and a control group for the prevention of PONV. We randomly assigned 57 women, 18 to 50 years old, undergoing laparoscopic procedures to 1 of 3 groups: (1) inhalation of 70% isopropyl alcohol, (2) 0.1 mg granisetron IV, and (3) no prophylactic treatment control. Participants were asked to rate their nausea and vomiting preoperatively, on arrival to postanesthesia care unit (PACU), at discharge from PACU, 6 hours after extubation, and 24 hours after extubation and any occurrence of nausea and vomiting using the numeric rating scale (NRS), 0 to 10. Group 1 experienced more PONV episodes than groups 2 and 3 during the 6- to 24-hour postsurgical timeframe (P = .02). There were no significant differences among the 3 groups in demographics, first episode of PONV, total number of episodes in 24 hours, NRS rating at rescue, and anesthetic duration. PONV and menstrual cycle phase had no positive correlation (P > .05). History of smoking, PONV, and motion sickness had no significant difference against any measure of PONV (P >.05).

AB - We evaluated preemptive treatment for postoperative nausea and vomiting (PONV) with intravenous (IV) granisetron, 0.1 mg, intraoperatively as compared with the use of 70% inhalation isopropyl alcohol and a control group for the prevention of PONV. We randomly assigned 57 women, 18 to 50 years old, undergoing laparoscopic procedures to 1 of 3 groups: (1) inhalation of 70% isopropyl alcohol, (2) 0.1 mg granisetron IV, and (3) no prophylactic treatment control. Participants were asked to rate their nausea and vomiting preoperatively, on arrival to postanesthesia care unit (PACU), at discharge from PACU, 6 hours after extubation, and 24 hours after extubation and any occurrence of nausea and vomiting using the numeric rating scale (NRS), 0 to 10. Group 1 experienced more PONV episodes than groups 2 and 3 during the 6- to 24-hour postsurgical timeframe (P = .02). There were no significant differences among the 3 groups in demographics, first episode of PONV, total number of episodes in 24 hours, NRS rating at rescue, and anesthetic duration. PONV and menstrual cycle phase had no positive correlation (P > .05). History of smoking, PONV, and motion sickness had no significant difference against any measure of PONV (P >.05).

KW - Granisetron

KW - Inhalation isopropyl alcohol

KW - Postoperative nausea and vomiting

UR - http://www.scopus.com/inward/record.url?scp=37249020932&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=37249020932&partnerID=8YFLogxK

M3 - Article

C2 - 18179001

AN - SCOPUS:37249020932

VL - 75

SP - 417

EP - 422

JO - AANA Journal

JF - AANA Journal

SN - 0094-6354

IS - 6

ER -