The Effects of Chronic Infection with a Superantigen-producing Virus

Leszek Ignatowicz, John Kappler, Philippa Marrack

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

Mice homozygous for a β2-microglobulin (β2-m) gene disruption lack β2-m protein and aredeficient for functional major histocompatibility complex class I (MHC-I) molecules. The mutantmice have normal numbers of CD4+8 - T helper cells, but lack MHC-I-directed CD4-8 +cytotoxic T lymphocytes (CTLs). In this study we used the β2-m mutant mice to study theimportance of MHC-I-directed immunity in skin graft rejection. Our results indicate that MHCI-directed CD8 + CTLs are not essential in the rejection of allografts with whole MHC ormultiple minor H differences. However, the absence of MHC-I-guided immunity profoundlyreduces the ability of mutant mice to reject H-Y disparate grafts. In addition, we show thatnatural killer cells which vigorously reject MHC-I-deficient bone marrow grafts, are not effectivein the destruction of MHC-I-deficient skin grafts.

Original languageEnglish (US)
Pages (from-to)885-893
Number of pages9
JournalJournal of Experimental Medicine
Volume175
Issue number4
DOIs
StatePublished - Apr 1 1992

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Superantigens
Major Histocompatibility Complex
Viruses
Infection
Cytotoxic T-Lymphocytes
Transplants
Immunity
Skin
Graft Rejection
Helper-Inducer T-Lymphocytes
Allografts
Bone Marrow
Genes
Proteins

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

The Effects of Chronic Infection with a Superantigen-producing Virus. / Ignatowicz, Leszek; Kappler, John; Marrack, Philippa.

In: Journal of Experimental Medicine, Vol. 175, No. 4, 01.04.1992, p. 885-893.

Research output: Contribution to journalArticle

Ignatowicz, Leszek ; Kappler, John ; Marrack, Philippa. / The Effects of Chronic Infection with a Superantigen-producing Virus. In: Journal of Experimental Medicine. 1992 ; Vol. 175, No. 4. pp. 885-893.
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