The permeability properties of dentin determine its sensitivity and the degree of pulpal response to restorative procedure materials and microleakage. Most pulpal reactions are due to bacteria or bacterial products that permeate across dentin. These reactions can be prevented if dentin is sealed with resins as soon as it is exposed. In the future, restorative dentists may employ topical application of biologic growth factors to permeate across dentin to modify the formation of reactionary or reparative dentin, thereby lowering dentin permeability and protecting the pulp.
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