The effects of pressure-induced cardiac hypertrophy on the functional capacity of the coronary circulation

Kevin C Dellsperger, Melvin L. Marcus

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Pressure-induced cardiac hypertrophy has many effects on the functional capacity of the coronary circulation. Many studies have been performed in both animal and humans and the major findings are as follows: Most types of myocardial hypertrophy are associated with the decrement in coronary vasodilator reserve; The magnitude of the decrement in coronary reserve in myocardial hypertrophy is usually much more prominent in patients with myocardial hypertrophy than in animal models; Left ventricular hypertrophy secondary to systemic hypertension is associated with altered autoregulation of myocardial perfusion; The perfusion abnormalities associated with hypertension and left ventricular hypertrophy are affected by various factors such as age of onset, ventricular involvement, and the stimulus for hypertrophy; Left ventricular hypertrophy secondary to renal hypertension markedly augments the adverse effects of coronary occlusion. In this setting, coronary occlusion is associated with a three-fold increase in the incidence of lethal ventricular arrhythmias and a 35% increase in infarct size. Thus, pressure-induced hypertrophy profoundly alters the coronary circulation. Am J Hypertens 1988; 1:200-207.

Original languageEnglish (US)
Pages (from-to)200-207
Number of pages8
JournalAmerican journal of hypertension
Volume1
Issue number2
DOIs
StatePublished - Jan 1 1988

Fingerprint

Coronary Circulation
Cardiomegaly
Hypertrophy
Pressure
Left Ventricular Hypertrophy
Coronary Occlusion
Perfusion
Hypertension
Renal Hypertension
Vasodilator Agents
Age of Onset
Cardiac Arrhythmias
Homeostasis
Animal Models
Incidence

Keywords

  • Coronary occlusion
  • Coronary vasodilator reserve
  • Myocardial hypertrophy
  • Myocardial perfusion
  • Pressure-induced cardiac hypertrophy

ASJC Scopus subject areas

  • Internal Medicine

Cite this

The effects of pressure-induced cardiac hypertrophy on the functional capacity of the coronary circulation. / Dellsperger, Kevin C; Marcus, Melvin L.

In: American journal of hypertension, Vol. 1, No. 2, 01.01.1988, p. 200-207.

Research output: Contribution to journalArticle

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