The effects of protein deficiency and fluoride on bone mineral content of rat tibia

Sopiato Likimani, Gary M. Whitford, M. E. Kunkel

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

This study examined the effects of chronic protein deficiency and fluoride administration (10 mg/kg/day), separately or in combination, on rat tibia properties. Protein deficiency increased the bone fluoride concentration and reduced the bone mineral content (BMC) especially at the proximal or growing end which contains mainly cancellous bone. Fluoride administration also reduced BMC, but to a lesser extent, and it resulted in proximal tibia fluoride concentrations that were nearly twice those of the distal tibia. The interaction between fluoride administration and the protein content of the diet on BMC was nonsignificant, suggesting that the effects were additive, not multiplicative or synergistic. Fluoride administration, but not protein deficiency, increased bone magnesium levels. It is hypothesized that the reduction in BMC in the areas where the fluoride concentrations were the highest was due to a localized toxic effect of fluoride.

Original languageEnglish (US)
Pages (from-to)157-164
Number of pages8
JournalCalcified Tissue International
Volume50
Issue number2
DOIs
StatePublished - Feb 1 1992

Fingerprint

Protein Deficiency
Tibia
Fluorides
Bone Density
Bone and Bones
Poisons
Magnesium
Diet

Keywords

  • Acid-base status
  • Fluorosis
  • Magnesium
  • Metabolism
  • Photon absorptiometry
  • Toxicity

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine
  • Endocrinology

Cite this

The effects of protein deficiency and fluoride on bone mineral content of rat tibia. / Likimani, Sopiato; Whitford, Gary M.; Kunkel, M. E.

In: Calcified Tissue International, Vol. 50, No. 2, 01.02.1992, p. 157-164.

Research output: Contribution to journalArticle

@article{5d0f5f6b2da64d3eabb38ebb245fc29c,
title = "The effects of protein deficiency and fluoride on bone mineral content of rat tibia",
abstract = "This study examined the effects of chronic protein deficiency and fluoride administration (10 mg/kg/day), separately or in combination, on rat tibia properties. Protein deficiency increased the bone fluoride concentration and reduced the bone mineral content (BMC) especially at the proximal or growing end which contains mainly cancellous bone. Fluoride administration also reduced BMC, but to a lesser extent, and it resulted in proximal tibia fluoride concentrations that were nearly twice those of the distal tibia. The interaction between fluoride administration and the protein content of the diet on BMC was nonsignificant, suggesting that the effects were additive, not multiplicative or synergistic. Fluoride administration, but not protein deficiency, increased bone magnesium levels. It is hypothesized that the reduction in BMC in the areas where the fluoride concentrations were the highest was due to a localized toxic effect of fluoride.",
keywords = "Acid-base status, Fluorosis, Magnesium, Metabolism, Photon absorptiometry, Toxicity",
author = "Sopiato Likimani and Whitford, {Gary M.} and Kunkel, {M. E.}",
year = "1992",
month = "2",
day = "1",
doi = "10.1007/BF00298794",
language = "English (US)",
volume = "50",
pages = "157--164",
journal = "Calcified Tissue International",
issn = "0171-967X",
publisher = "Springer New York",
number = "2",

}

TY - JOUR

T1 - The effects of protein deficiency and fluoride on bone mineral content of rat tibia

AU - Likimani, Sopiato

AU - Whitford, Gary M.

AU - Kunkel, M. E.

PY - 1992/2/1

Y1 - 1992/2/1

N2 - This study examined the effects of chronic protein deficiency and fluoride administration (10 mg/kg/day), separately or in combination, on rat tibia properties. Protein deficiency increased the bone fluoride concentration and reduced the bone mineral content (BMC) especially at the proximal or growing end which contains mainly cancellous bone. Fluoride administration also reduced BMC, but to a lesser extent, and it resulted in proximal tibia fluoride concentrations that were nearly twice those of the distal tibia. The interaction between fluoride administration and the protein content of the diet on BMC was nonsignificant, suggesting that the effects were additive, not multiplicative or synergistic. Fluoride administration, but not protein deficiency, increased bone magnesium levels. It is hypothesized that the reduction in BMC in the areas where the fluoride concentrations were the highest was due to a localized toxic effect of fluoride.

AB - This study examined the effects of chronic protein deficiency and fluoride administration (10 mg/kg/day), separately or in combination, on rat tibia properties. Protein deficiency increased the bone fluoride concentration and reduced the bone mineral content (BMC) especially at the proximal or growing end which contains mainly cancellous bone. Fluoride administration also reduced BMC, but to a lesser extent, and it resulted in proximal tibia fluoride concentrations that were nearly twice those of the distal tibia. The interaction between fluoride administration and the protein content of the diet on BMC was nonsignificant, suggesting that the effects were additive, not multiplicative or synergistic. Fluoride administration, but not protein deficiency, increased bone magnesium levels. It is hypothesized that the reduction in BMC in the areas where the fluoride concentrations were the highest was due to a localized toxic effect of fluoride.

KW - Acid-base status

KW - Fluorosis

KW - Magnesium

KW - Metabolism

KW - Photon absorptiometry

KW - Toxicity

UR - http://www.scopus.com/inward/record.url?scp=0026519763&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026519763&partnerID=8YFLogxK

U2 - 10.1007/BF00298794

DO - 10.1007/BF00298794

M3 - Article

VL - 50

SP - 157

EP - 164

JO - Calcified Tissue International

JF - Calcified Tissue International

SN - 0171-967X

IS - 2

ER -