The effects of theophylline and 3-isobutyl-1-methylxanthine on the contractility, cyclic AMP content and phosphodiesterase activity of the M. Mercenaria ventricle

Stephen D. Hess, Paul D. Reiss, William Joseph Higgins

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

1. Theophylline and 3-isobutyl-1-methylxanthine (IBMX) are relatively poor inhibitors of cyclic AMP phosphodiesterase from the ventricles of the bivalve Mercenaria mercenaria (I50 = 4.5 × 10-3 and 2 × 10-3 M, respectively). 2. At doses ≤10-4 M, these agents have no effect on myocardial contractility or cyclic AMP content. 3. However, IBMX (10-4 M) does potentiate the cardio-excitatory actions of a subthreshold of 5-hydroxytryptamine.

Original languageEnglish (US)
Pages (from-to)13-18
Number of pages6
JournalComparative Biochemistry and Physiology. Part C, Comparative
Volume69
Issue number1
DOIs
StatePublished - Jan 1 1981

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Mercenaria
1-Methyl-3-isobutylxanthine
Phosphoric Diester Hydrolases
Theophylline
Cyclic AMP
Bivalvia
Serotonin

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

Cite this

The effects of theophylline and 3-isobutyl-1-methylxanthine on the contractility, cyclic AMP content and phosphodiesterase activity of the M. Mercenaria ventricle. / Hess, Stephen D.; Reiss, Paul D.; Higgins, William Joseph.

In: Comparative Biochemistry and Physiology. Part C, Comparative, Vol. 69, No. 1, 01.01.1981, p. 13-18.

Research output: Contribution to journalArticle

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