The efficacy of laser therapy in the treatment of cervical intraepithelial neoplasia

Robert V. Higgins, John R. van Nagell, Elvis S. Donaldson, Holly H. Gallion, Edward J. Pavlik, Richard J. Kryscio

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

The efficacy of carbon dioxide laser therapy in the treatment of cervical intraepithelial neoplasia (CIN) was evaluated in 253 patients treated at the University of Kentucky Medical Center from 1984 to 1987. All patients had histologically confirmed CIN and were treated in an outpatient setting. Parameters examined included severity of neoplasia, presence of koilocytosis on biopsy, depth of laser ablation, and the number of cervical quadrants involved by CIN. Following therapy, patients were examined at 3-month intervals from 12 to 48 months (mean 18 months). Eighty-nine per cent of patients were successfully treated with one laser ablation and all patients were cured of disease with two treatments. Over 70% of patients initially failing therapy had CIN III or ≥ 3 quadrant disease. The most significant predictor of failure was lesion size. Only 74% of women with 3 or 4 quadrant disease were successfully treated with one treatment. No patient experienced postoperative infection or bleeding requiring treatment. These data confirm that carbon dioxide laser therapy is a safe and highly effective treatment method for all forms of CIN.

Original languageEnglish (US)
Pages (from-to)79-81
Number of pages3
JournalGynecologic Oncology
Volume36
Issue number1
DOIs
StatePublished - Jan 1990
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology

Fingerprint Dive into the research topics of 'The efficacy of laser therapy in the treatment of cervical intraepithelial neoplasia'. Together they form a unique fingerprint.

  • Cite this

    Higgins, R. V., van Nagell, J. R., Donaldson, E. S., Gallion, H. H., Pavlik, E. J., & Kryscio, R. J. (1990). The efficacy of laser therapy in the treatment of cervical intraepithelial neoplasia. Gynecologic Oncology, 36(1), 79-81. https://doi.org/10.1016/0090-8258(90)90112-X