The elston-stewart algorithm for continuous genotypes and environmental factors

Robert C. Elston, Varghese George, Forrestt Severtson

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

The Elston-Stewart algorithm for a normally distributed trait under a polygenic model is explained in detail and extended to allow for other continuous environmental variables. This formulation is especially useful for large pedigrees, as it avoids the need to invert matrices. Whereas it may not be feasible by this method to estimate all the various components of previously suggested models for polygenic inheritance, it can allow for a reasonably flexible pedigree correlational structure under which valid tests can be performed for fixed effects that may affect the phenotype.

Original languageEnglish (US)
Pages (from-to)16-27
Number of pages12
JournalHuman Heredity
Volume42
Issue number1
DOIs
StatePublished - Jan 1 1992
Externally publishedYes

Fingerprint

Pedigree
Genotype
Multifactorial Inheritance
Phenotype

Keywords

  • Familial correlations
  • Multinormal density
  • Pedigree analysis
  • Polygenic model

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

The elston-stewart algorithm for continuous genotypes and environmental factors. / Elston, Robert C.; George, Varghese; Severtson, Forrestt.

In: Human Heredity, Vol. 42, No. 1, 01.01.1992, p. 16-27.

Research output: Contribution to journalArticle

Elston, Robert C. ; George, Varghese ; Severtson, Forrestt. / The elston-stewart algorithm for continuous genotypes and environmental factors. In: Human Heredity. 1992 ; Vol. 42, No. 1. pp. 16-27.
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