TY - JOUR
T1 - The Environmental Determinants of Diabetes in the Young (TEDDY) Study
T2 - 2018 Update
AU - The TEDDY study group
AU - Rewers, Marian
AU - Hyöty, Heikki
AU - Lernmark, Åke
AU - Hagopian, William
AU - She, Jin Xiong
AU - Schatz, Desmond
AU - Ziegler, Anette G.
AU - Toppari, Jorma
AU - Akolkar, Beena
AU - She, Jin-Xiong
AU - Rewers, Marian
AU - Bautista, Kimberly
AU - Baxter, Judith
AU - Felipe-Morales, Daniel
AU - Driscoll, Kimberly
AU - Frohnert, Brigitte I.
AU - Gallant, Marisa
AU - Gesualdo, Patricia
AU - Hoffman, Michelle
AU - Karban, Rachel
AU - Liu, Edwin
AU - Norris, Jill
AU - Samper-Imaz, Adela
AU - Steck, Andrea
AU - Waugh, Kathleen
AU - Wright, Hali
AU - Toppari, Jorma
AU - Simell, Olli G.
AU - Adamsson, Annika
AU - Ahonen, Suvi
AU - Hyöty, Heikki
AU - Ilonen, Jorma
AU - Jokipuu, Sanna
AU - Karlsson, Leena
AU - Kähönenμ, Miia
AU - Knip, Mikael
AU - Koreasalo, Mirva
AU - Kurppa, Kalle
AU - Latva-ahoμ, Tiina
AU - Lönnrot, Maria
AU - Mattila, Markus
AU - Mäntymäki, Elina
AU - Multasuoμ, Katja
AU - Niininen, Tiina
AU - Niinistö, Sari
AU - Nyblom, Mia
AU - Oikarinen, Sami
AU - Ollikainenμ, Paula
AU - Rajala, Petra
AU - McIndoe, Richard A
N1 - Funding Information:
Funding Information The TEDDY Study is funded by U01 DK63829, U01 DK63861, U01 DK63821, U01 DK63865, U01 DK63863, U01 DK63836, U01 DK63790, UC4 DK63829, UC4 DK63861, UC4 DK63821, UC4 DK63865, UC4 DK63863, UC4 DK63836, UC4 DK95300, UC4 DK100238, UC4 DK106955, UC4 DK112243, UC4 DK117483, and Contract No. HHSN267200700014C from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institute of Allergy and Infectious Diseases (NIAID), National Institute of Child Health and Human Development (NICHD), National Institute of Environmental Health Sciences (NIEHS), Centers for Disease Control and Prevention (CDC), and JDRF. This work supported in part by the NIH/NCATS Clinical and Translational Science Awards to the University of Florida (UL1 TR000064) and the University of Colorado (UL1 TR001082).
Funding Information:
Heikki Hyöty reports grants from National Institute of Health (NIH) to carry out the TEDDY study; and being a Shareholder and member of the board of Vactech Ltd., which develops vaccines against picornaviruses.
PY - 2018/12/1
Y1 - 2018/12/1
N2 - Purpose of Review: The environmental triggers of islet autoimmunity leading to type 1 diabetes (T1D) need to be elucidated to inform primary prevention. The Environmental Determinants of Diabetes in the Young (TEDDY) Study follows from birth 8676 children with T1D risk HLA-DR-DQ genotypes in the USA, Finland, Germany, and Sweden. Most study participants (89%) have no first-degree relative with T1D. The primary outcomes include the appearance of one or more persistent islet autoantibodies (islet autoimmunity, IA) and clinical T1D. Recent Findings: As of February 28, 2018, 769 children had developed IA and 310 have progressed to T1D. Secondary outcomes include celiac disease and autoimmune thyroid disease. While the follow-up continues, TEDDY has already evaluated a number of candidate environmental triggers, including infections, probiotics, micronutrient, and microbiome. Summary: TEDDY results suggest that there are multiple pathways leading to the destruction of pancreatic beta-cells. Ongoing measurements of further specific exposures, gene variants, and gene-environment interactions and detailed “omics” studies will provide novel information on the pathogenesis of T1D.
AB - Purpose of Review: The environmental triggers of islet autoimmunity leading to type 1 diabetes (T1D) need to be elucidated to inform primary prevention. The Environmental Determinants of Diabetes in the Young (TEDDY) Study follows from birth 8676 children with T1D risk HLA-DR-DQ genotypes in the USA, Finland, Germany, and Sweden. Most study participants (89%) have no first-degree relative with T1D. The primary outcomes include the appearance of one or more persistent islet autoantibodies (islet autoimmunity, IA) and clinical T1D. Recent Findings: As of February 28, 2018, 769 children had developed IA and 310 have progressed to T1D. Secondary outcomes include celiac disease and autoimmune thyroid disease. While the follow-up continues, TEDDY has already evaluated a number of candidate environmental triggers, including infections, probiotics, micronutrient, and microbiome. Summary: TEDDY results suggest that there are multiple pathways leading to the destruction of pancreatic beta-cells. Ongoing measurements of further specific exposures, gene variants, and gene-environment interactions and detailed “omics” studies will provide novel information on the pathogenesis of T1D.
KW - Autoimmunity
KW - Children
KW - Type 1 diabetes
UR - http://www.scopus.com/inward/record.url?scp=85055450125&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85055450125&partnerID=8YFLogxK
U2 - 10.1007/s11892-018-1113-2
DO - 10.1007/s11892-018-1113-2
M3 - Review article
C2 - 30353256
AN - SCOPUS:85055450125
VL - 18
JO - Current Diabetes Reports
JF - Current Diabetes Reports
SN - 1534-4827
IS - 12
M1 - 136
ER -