TY - JOUR
T1 - The Environmental Determinants of Diabetes in the Young (TEDDY) Study
T2 - 2018 Update
AU - The TEDDY study group
AU - Rewers, Marian
AU - Hyöty, Heikki
AU - Lernmark, Åke
AU - Hagopian, William
AU - She, Jin Xiong
AU - Schatz, Desmond
AU - Ziegler, Anette G.
AU - Toppari, Jorma
AU - Akolkar, Beena
AU - She, Jin-Xiong
AU - Rewers, Marian
AU - Bautista, Kimberly
AU - Baxter, Judith
AU - Felipe-Morales, Daniel
AU - Driscoll, Kimberly
AU - Frohnert, Brigitte I.
AU - Gallant, Marisa
AU - Gesualdo, Patricia
AU - Hoffman, Michelle
AU - Karban, Rachel
AU - Liu, Edwin
AU - Norris, Jill
AU - Samper-Imaz, Adela
AU - Steck, Andrea
AU - Waugh, Kathleen
AU - Wright, Hali
AU - Toppari, Jorma
AU - Simell, Olli G.
AU - Adamsson, Annika
AU - Ahonen, Suvi
AU - Hyöty, Heikki
AU - Ilonen, Jorma
AU - Jokipuu, Sanna
AU - Karlsson, Leena
AU - Kähönenμ, Miia
AU - Knip, Mikael
AU - Koreasalo, Mirva
AU - Kurppa, Kalle
AU - Latva-ahoμ, Tiina
AU - Lönnrot, Maria
AU - Mattila, Markus
AU - Mäntymäki, Elina
AU - Multasuoμ, Katja
AU - Niininen, Tiina
AU - Niinistö, Sari
AU - Nyblom, Mia
AU - Oikarinen, Sami
AU - Ollikainenμ, Paula
AU - Rajala, Petra
AU - McIndoe, Richard A
PY - 2018/12/1
Y1 - 2018/12/1
N2 - Purpose of Review: The environmental triggers of islet autoimmunity leading to type 1 diabetes (T1D) need to be elucidated to inform primary prevention. The Environmental Determinants of Diabetes in the Young (TEDDY) Study follows from birth 8676 children with T1D risk HLA-DR-DQ genotypes in the USA, Finland, Germany, and Sweden. Most study participants (89%) have no first-degree relative with T1D. The primary outcomes include the appearance of one or more persistent islet autoantibodies (islet autoimmunity, IA) and clinical T1D. Recent Findings: As of February 28, 2018, 769 children had developed IA and 310 have progressed to T1D. Secondary outcomes include celiac disease and autoimmune thyroid disease. While the follow-up continues, TEDDY has already evaluated a number of candidate environmental triggers, including infections, probiotics, micronutrient, and microbiome. Summary: TEDDY results suggest that there are multiple pathways leading to the destruction of pancreatic beta-cells. Ongoing measurements of further specific exposures, gene variants, and gene-environment interactions and detailed “omics” studies will provide novel information on the pathogenesis of T1D.
AB - Purpose of Review: The environmental triggers of islet autoimmunity leading to type 1 diabetes (T1D) need to be elucidated to inform primary prevention. The Environmental Determinants of Diabetes in the Young (TEDDY) Study follows from birth 8676 children with T1D risk HLA-DR-DQ genotypes in the USA, Finland, Germany, and Sweden. Most study participants (89%) have no first-degree relative with T1D. The primary outcomes include the appearance of one or more persistent islet autoantibodies (islet autoimmunity, IA) and clinical T1D. Recent Findings: As of February 28, 2018, 769 children had developed IA and 310 have progressed to T1D. Secondary outcomes include celiac disease and autoimmune thyroid disease. While the follow-up continues, TEDDY has already evaluated a number of candidate environmental triggers, including infections, probiotics, micronutrient, and microbiome. Summary: TEDDY results suggest that there are multiple pathways leading to the destruction of pancreatic beta-cells. Ongoing measurements of further specific exposures, gene variants, and gene-environment interactions and detailed “omics” studies will provide novel information on the pathogenesis of T1D.
KW - Autoimmunity
KW - Children
KW - Type 1 diabetes
UR - http://www.scopus.com/inward/record.url?scp=85055450125&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85055450125&partnerID=8YFLogxK
U2 - 10.1007/s11892-018-1113-2
DO - 10.1007/s11892-018-1113-2
M3 - Review article
C2 - 30353256
AN - SCOPUS:85055450125
VL - 18
JO - Current Diabetes Reports
JF - Current Diabetes Reports
SN - 1534-4827
IS - 12
M1 - 136
ER -