The Environmental Determinants of Diabetes in the Young (TEDDY) Study: 2018 Update

The TEDDY study group

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Purpose of Review: The environmental triggers of islet autoimmunity leading to type 1 diabetes (T1D) need to be elucidated to inform primary prevention. The Environmental Determinants of Diabetes in the Young (TEDDY) Study follows from birth 8676 children with T1D risk HLA-DR-DQ genotypes in the USA, Finland, Germany, and Sweden. Most study participants (89%) have no first-degree relative with T1D. The primary outcomes include the appearance of one or more persistent islet autoantibodies (islet autoimmunity, IA) and clinical T1D. Recent Findings: As of February 28, 2018, 769 children had developed IA and 310 have progressed to T1D. Secondary outcomes include celiac disease and autoimmune thyroid disease. While the follow-up continues, TEDDY has already evaluated a number of candidate environmental triggers, including infections, probiotics, micronutrient, and microbiome. Summary: TEDDY results suggest that there are multiple pathways leading to the destruction of pancreatic beta-cells. Ongoing measurements of further specific exposures, gene variants, and gene-environment interactions and detailed “omics” studies will provide novel information on the pathogenesis of T1D.

Original languageEnglish (US)
Article number136
JournalCurrent Diabetes Reports
Volume18
Issue number12
DOIs
StatePublished - Dec 1 2018

Fingerprint

Type 1 Diabetes Mellitus
Autoimmunity
HLA-DQ Antigens
Gene-Environment Interaction
Micronutrients
Microbiota
Thyroid Diseases
Probiotics
Insulin-Secreting Cells
Celiac Disease
HLA-DR Antigens
Primary Prevention
Finland
Sweden
Autoantibodies
Autoimmune Diseases
Germany
Genotype
Parturition
Infection

Keywords

  • Autoimmunity
  • Children
  • Type 1 diabetes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

The Environmental Determinants of Diabetes in the Young (TEDDY) Study : 2018 Update. / The TEDDY study group.

In: Current Diabetes Reports, Vol. 18, No. 12, 136, 01.12.2018.

Research output: Contribution to journalReview article

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title = "The Environmental Determinants of Diabetes in the Young (TEDDY) Study: 2018 Update",
abstract = "Purpose of Review: The environmental triggers of islet autoimmunity leading to type 1 diabetes (T1D) need to be elucidated to inform primary prevention. The Environmental Determinants of Diabetes in the Young (TEDDY) Study follows from birth 8676 children with T1D risk HLA-DR-DQ genotypes in the USA, Finland, Germany, and Sweden. Most study participants (89{\%}) have no first-degree relative with T1D. The primary outcomes include the appearance of one or more persistent islet autoantibodies (islet autoimmunity, IA) and clinical T1D. Recent Findings: As of February 28, 2018, 769 children had developed IA and 310 have progressed to T1D. Secondary outcomes include celiac disease and autoimmune thyroid disease. While the follow-up continues, TEDDY has already evaluated a number of candidate environmental triggers, including infections, probiotics, micronutrient, and microbiome. Summary: TEDDY results suggest that there are multiple pathways leading to the destruction of pancreatic beta-cells. Ongoing measurements of further specific exposures, gene variants, and gene-environment interactions and detailed “omics” studies will provide novel information on the pathogenesis of T1D.",
keywords = "Autoimmunity, Children, Type 1 diabetes",
author = "{The TEDDY study group} and Marian Rewers and Heikki Hy{\"o}ty and {\AA}ke Lernmark and William Hagopian and She, {Jin Xiong} and Desmond Schatz and Ziegler, {Anette G.} and Jorma Toppari and Beena Akolkar and Jin-Xiong She and Marian Rewers and Kimberly Bautista and Judith Baxter and Daniel Felipe-Morales and Kimberly Driscoll and Frohnert, {Brigitte I.} and Marisa Gallant and Patricia Gesualdo and Michelle Hoffman and Rachel Karban and Edwin Liu and Jill Norris and Adela Samper-Imaz and Andrea Steck and Kathleen Waugh and Hali Wright and Jorma Toppari and Simell, {Olli G.} and Annika Adamsson and Suvi Ahonen and Heikki Hy{\"o}ty and Jorma Ilonen and Sanna Jokipuu and Leena Karlsson and Miia K{\"a}h{\"o}nenμ and Mikael Knip and Mirva Koreasalo and Kalle Kurppa and Tiina Latva-ahoμ and Maria L{\"o}nnrot and Markus Mattila and Elina M{\"a}ntym{\"a}ki and Katja Multasuoμ and Tiina Niininen and Sari Niinist{\"o} and Mia Nyblom and Sami Oikarinen and Paula Ollikainenμ and Petra Rajala and McIndoe, {Richard A}",
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N2 - Purpose of Review: The environmental triggers of islet autoimmunity leading to type 1 diabetes (T1D) need to be elucidated to inform primary prevention. The Environmental Determinants of Diabetes in the Young (TEDDY) Study follows from birth 8676 children with T1D risk HLA-DR-DQ genotypes in the USA, Finland, Germany, and Sweden. Most study participants (89%) have no first-degree relative with T1D. The primary outcomes include the appearance of one or more persistent islet autoantibodies (islet autoimmunity, IA) and clinical T1D. Recent Findings: As of February 28, 2018, 769 children had developed IA and 310 have progressed to T1D. Secondary outcomes include celiac disease and autoimmune thyroid disease. While the follow-up continues, TEDDY has already evaluated a number of candidate environmental triggers, including infections, probiotics, micronutrient, and microbiome. Summary: TEDDY results suggest that there are multiple pathways leading to the destruction of pancreatic beta-cells. Ongoing measurements of further specific exposures, gene variants, and gene-environment interactions and detailed “omics” studies will provide novel information on the pathogenesis of T1D.

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