The epidemiology of idiopathic dilated cardiomyopathy in a biracial community

Steven Scott Coughlin, Moyses Szklo, Kenneth Baughman, Thomas A. Pearson

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

An epidemiologic study of idiopathic dilated cardiomyopathy was carried out in order to identity possible risk factors for this often fatal cause of heart failure in young adults. Possible associations with black race and other genetic and environmental factors were examined by comparing newly diagnosed cases ascertained from four Baltimore hospitals (n=95) with neighborhood controls (n=95), matched on sex and 5-year age intervals. Matched and unmatched relative odds and conditional logistic regression coefficients were obtained to describe the associations. Statistically significant, independent associations were observed between idiopathic dilated cardiomyopathy and black race, low annual income, and history of asthma (p <0.05). The black predominance (relative odds=2.7, 95% confidence interval 2.0-3.4) was not explained by income, alcohol consumption, cigarette usage, body mass index, hypertension, or asthma. A possible interactive eftect was observed between black race and history of asthma and other atopic diseases. Thus, blacks, especially those with a history of hypersensitivity, may represent a high-risk subgroup in need of preventive care or early intervention.

Original languageEnglish (US)
Pages (from-to)48-56
Number of pages9
JournalAmerican journal of epidemiology
Volume131
Issue number1
DOIs
StatePublished - Jan 1 1990
Externally publishedYes

Fingerprint

Dilated Cardiomyopathy
Epidemiology
Asthma
Odds Ratio
Baltimore
Preventive Medicine
Tobacco Products
Alcohol Drinking
Epidemiologic Studies
Young Adult
Hypersensitivity
Body Mass Index
Heart Failure
Logistic Models
Confidence Intervals
Hypertension

Keywords

  • Alcohol, ethyl
  • Asthma
  • Blacks
  • Cardiomyopathy, congestive
  • Hypersensitivity
  • Hypertension
  • Obesity
  • Smoking

ASJC Scopus subject areas

  • Epidemiology

Cite this

The epidemiology of idiopathic dilated cardiomyopathy in a biracial community. / Coughlin, Steven Scott; Szklo, Moyses; Baughman, Kenneth; Pearson, Thomas A.

In: American journal of epidemiology, Vol. 131, No. 1, 01.01.1990, p. 48-56.

Research output: Contribution to journalArticle

Coughlin, Steven Scott ; Szklo, Moyses ; Baughman, Kenneth ; Pearson, Thomas A. / The epidemiology of idiopathic dilated cardiomyopathy in a biracial community. In: American journal of epidemiology. 1990 ; Vol. 131, No. 1. pp. 48-56.
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