The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory

Joseph Zhuo Tsien, Patricio T. Huerta, Susumu Tonegawa

Research output: Contribution to journalArticle

1261 Citations (Scopus)

Abstract

We have produced a mouse strain in which the deletion of the NMDAR1 gene is restricted to the CA1 pyramidal cells of the hippocampus by using a new and general method that allows CA1-restricted gene knockout. The mutant mice grow into adulthood without obvious abnormalities. Adult mice lack NMDA receptor-mediated synaptic currents and long-term potentiation in the CA1 synapses and exhibit impaired spatial memory but unimpaired nonspatial learning. Our results strongly suggest that activity-dependent modifications of CA1 synapses, mediated by NMDA receptors, play an essential role in the acquisition of spatial memories.

Original languageEnglish (US)
Pages (from-to)1327-1338
Number of pages12
JournalCell
Volume87
Issue number7
DOIs
StatePublished - Dec 27 1996
Externally publishedYes

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Neuronal Plasticity
N-Methyl-D-Aspartate Receptors
Plasticity
Genes
Data storage equipment
Synapses
Gene Knockout Techniques
Long-Term Potentiation
Pyramidal Cells
Gene Deletion
Hippocampus
Learning
Spatial Memory
NMDA receptor A1

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory. / Tsien, Joseph Zhuo; Huerta, Patricio T.; Tonegawa, Susumu.

In: Cell, Vol. 87, No. 7, 27.12.1996, p. 1327-1338.

Research output: Contribution to journalArticle

Tsien, Joseph Zhuo ; Huerta, Patricio T. ; Tonegawa, Susumu. / The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory. In: Cell. 1996 ; Vol. 87, No. 7. pp. 1327-1338.
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