The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory

Joe Z. Tsien; Patricio T. Huerta; Susumu Tonegawa

doi:10.1016/S0092-8674(00)81827-9

The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory

Joe Z. Tsien, Patricio T. Huerta, Susumu Tonegawa

Research output: Contribution to journal › Article › peer-review

1447 Scopus citations

Abstract

We have produced a mouse strain in which the deletion of the NMDAR1 gene is restricted to the CA1 pyramidal cells of the hippocampus by using a new and general method that allows CA1-restricted gene knockout. The mutant mice grow into adulthood without obvious abnormalities. Adult mice lack NMDA receptor-mediated synaptic currents and long-term potentiation in the CA1 synapses and exhibit impaired spatial memory but unimpaired nonspatial learning. Our results strongly suggest that activity-dependent modifications of CA1 synapses, mediated by NMDA receptors, play an essential role in the acquisition of spatial memories.

Original language	English (US)
Pages (from-to)	1327-1338
Number of pages	12
Journal	Cell
Volume	87
Issue number	7
DOIs	https://doi.org/10.1016/S0092-8674(00)81827-9
State	Published - Dec 27 1996
Externally published	Yes

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1016/S0092-8674(00)81827-9

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title = "The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory",

abstract = "We have produced a mouse strain in which the deletion of the NMDAR1 gene is restricted to the CA1 pyramidal cells of the hippocampus by using a new and general method that allows CA1-restricted gene knockout. The mutant mice grow into adulthood without obvious abnormalities. Adult mice lack NMDA receptor-mediated synaptic currents and long-term potentiation in the CA1 synapses and exhibit impaired spatial memory but unimpaired nonspatial learning. Our results strongly suggest that activity-dependent modifications of CA1 synapses, mediated by NMDA receptors, play an essential role in the acquisition of spatial memories.",

author = "Tsien, {Joe Z.} and Huerta, {Patricio T.} and Susumu Tonegawa",

note = "Funding Information: We would like to thank Jason Derwin, Tamara Ochoa, and Cindy Tom for their assistance; Kenneth I. Blum and Takuji Iwasato for comments on the manuscript, Athanassios Siapas for help with Figure 8c ; and Matthew Wilson for insightful discussion and guidance throughout this project. This work was supported by National Institutes of Health grant number NS32925 and by gifts from Shionogi Institute for Medical Science and Amgen, Inc. (all to S. T.). P. T. H. was also supported by the Pew Latin American Fellows Program.",

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AU - Tonegawa, Susumu

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N2 - We have produced a mouse strain in which the deletion of the NMDAR1 gene is restricted to the CA1 pyramidal cells of the hippocampus by using a new and general method that allows CA1-restricted gene knockout. The mutant mice grow into adulthood without obvious abnormalities. Adult mice lack NMDA receptor-mediated synaptic currents and long-term potentiation in the CA1 synapses and exhibit impaired spatial memory but unimpaired nonspatial learning. Our results strongly suggest that activity-dependent modifications of CA1 synapses, mediated by NMDA receptors, play an essential role in the acquisition of spatial memories.

AB - We have produced a mouse strain in which the deletion of the NMDAR1 gene is restricted to the CA1 pyramidal cells of the hippocampus by using a new and general method that allows CA1-restricted gene knockout. The mutant mice grow into adulthood without obvious abnormalities. Adult mice lack NMDA receptor-mediated synaptic currents and long-term potentiation in the CA1 synapses and exhibit impaired spatial memory but unimpaired nonspatial learning. Our results strongly suggest that activity-dependent modifications of CA1 synapses, mediated by NMDA receptors, play an essential role in the acquisition of spatial memories.

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The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory

Abstract

ASJC Scopus subject areas

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