The expression and functions of glycoconjugates in neural stem cells

Makoto Yanagisawa, Robert K Yu

Research output: Contribution to journalReview article

99 Citations (Scopus)

Abstract

The mammalian central nervous system is organized by a variety of cells such as neurons and glial cells. These cells are generated from a common progenitor, the neural stem cell (NSC). NSCs are defined as undifferentiated neural cells that are characterized by their high proliferative potential while retaining the capacity for self-renewal and multipotency. Glycoconjugates carrying carbohydrate antigens, including glycoproteins, glycolipids, and proteoglycans, are primarily localized on the plasma-membrane surface of cells and serve as excellent biomarkers at various stages of cellular differentiation. Moreover, they also play important functional roles in determining cell fate such as self-renewal, proliferation, and differentiation. In the present review, we discuss the expression pattern and possible functions of glycoconjugates and carbohydrate antigens in NSCs, with an emphasis on stage-specific embryonic antigen-1, human natural killer antigen-1, polysialic acid-neural cell-adhesion molecule, prominin-1, gp130, chondroitin sulfate proteoglycans, heparan sulfate proteoglycans, cystatin C, galectin-1, glycolipids, and Notch.

Original languageEnglish (US)
JournalGlycobiology
Volume17
Issue number7
DOIs
StatePublished - Jul 1 2007

Fingerprint

Glycoconjugates
Neural Stem Cells
Stem cells
Glycolipids
Antigens
CD15 Antigens
Carbohydrates
Galectin 1
Chondroitin Sulfate Proteoglycans
Cystatin C
Neural Cell Adhesion Molecules
Heparan Sulfate Proteoglycans
Neurology
Biomarkers
Proteoglycans
Cell membranes
Neurons
Glycoproteins
Neuroglia
Central Nervous System

Keywords

  • Development
  • Glycolipids
  • Glycoproteins
  • Niche
  • Proteoglycans

ASJC Scopus subject areas

  • Biochemistry

Cite this

The expression and functions of glycoconjugates in neural stem cells. / Yanagisawa, Makoto; Yu, Robert K.

In: Glycobiology, Vol. 17, No. 7, 01.07.2007.

Research output: Contribution to journalReview article

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