The frequency-dependent behavior of cerebral autoregulation

Cole A. Giller

Research output: Contribution to journalArticle

186 Citations (Scopus)

Abstract

Cerebral autoregulation is a complex physiological process composed of both fast and slow components that may respond differently to different rates and patterns of blood pressure variation. To assess the temporal nature of autoregulation, transcranial Doppler velocity recordings of the middle cerebral artery obtained over prolonged periods were compared with blood pressure recordings in 5 patients without cerebral disease and in 13 patients with intracranial pathological changes. Correlations between the velocity and pressure wave forms at various frequencies of variation were measured with systems analysis techniques. Patients with aneurysmal subarachnoid hemorrhage had high correlations indicating pressure-dependent flow and impaired autoregulation. Patients without cerebral disease had significantly lower correlations (P < 0.01), indicating intact autoregulation. Examples of increasing correlations and correlations at new frequencies emerging as the clinical condition worsened are given. These preliminary examples suggest that the application of systems analysis techniques to velocity and pressure data allow measurement of the temporal nature of cerebral autoregulation.

Original languageEnglish (US)
Pages (from-to)362-368
Number of pages7
JournalNeurosurgery
Volume27
Issue number3
DOIs
StatePublished - Jan 1 1990
Externally publishedYes

Fingerprint

Homeostasis
Systems Analysis
Pressure
Physiological Phenomena
Blood Pressure
Middle Cerebral Artery
Subarachnoid Hemorrhage

Keywords

  • cerebral aneurysm
  • cerebral autoregulation
  • transcranial Doppler ultrasound

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

The frequency-dependent behavior of cerebral autoregulation. / Giller, Cole A.

In: Neurosurgery, Vol. 27, No. 3, 01.01.1990, p. 362-368.

Research output: Contribution to journalArticle

Giller, Cole A. / The frequency-dependent behavior of cerebral autoregulation. In: Neurosurgery. 1990 ; Vol. 27, No. 3. pp. 362-368.
@article{c8ceee3c33e742188ec0efcdd7c57101,
title = "The frequency-dependent behavior of cerebral autoregulation",
abstract = "Cerebral autoregulation is a complex physiological process composed of both fast and slow components that may respond differently to different rates and patterns of blood pressure variation. To assess the temporal nature of autoregulation, transcranial Doppler velocity recordings of the middle cerebral artery obtained over prolonged periods were compared with blood pressure recordings in 5 patients without cerebral disease and in 13 patients with intracranial pathological changes. Correlations between the velocity and pressure wave forms at various frequencies of variation were measured with systems analysis techniques. Patients with aneurysmal subarachnoid hemorrhage had high correlations indicating pressure-dependent flow and impaired autoregulation. Patients without cerebral disease had significantly lower correlations (P < 0.01), indicating intact autoregulation. Examples of increasing correlations and correlations at new frequencies emerging as the clinical condition worsened are given. These preliminary examples suggest that the application of systems analysis techniques to velocity and pressure data allow measurement of the temporal nature of cerebral autoregulation.",
keywords = "cerebral aneurysm, cerebral autoregulation, transcranial Doppler ultrasound",
author = "Giller, {Cole A.}",
year = "1990",
month = "1",
day = "1",
doi = "10.1227/00006123-199009000-00004",
language = "English (US)",
volume = "27",
pages = "362--368",
journal = "Neurosurgery",
issn = "0148-396X",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - The frequency-dependent behavior of cerebral autoregulation

AU - Giller, Cole A.

PY - 1990/1/1

Y1 - 1990/1/1

N2 - Cerebral autoregulation is a complex physiological process composed of both fast and slow components that may respond differently to different rates and patterns of blood pressure variation. To assess the temporal nature of autoregulation, transcranial Doppler velocity recordings of the middle cerebral artery obtained over prolonged periods were compared with blood pressure recordings in 5 patients without cerebral disease and in 13 patients with intracranial pathological changes. Correlations between the velocity and pressure wave forms at various frequencies of variation were measured with systems analysis techniques. Patients with aneurysmal subarachnoid hemorrhage had high correlations indicating pressure-dependent flow and impaired autoregulation. Patients without cerebral disease had significantly lower correlations (P < 0.01), indicating intact autoregulation. Examples of increasing correlations and correlations at new frequencies emerging as the clinical condition worsened are given. These preliminary examples suggest that the application of systems analysis techniques to velocity and pressure data allow measurement of the temporal nature of cerebral autoregulation.

AB - Cerebral autoregulation is a complex physiological process composed of both fast and slow components that may respond differently to different rates and patterns of blood pressure variation. To assess the temporal nature of autoregulation, transcranial Doppler velocity recordings of the middle cerebral artery obtained over prolonged periods were compared with blood pressure recordings in 5 patients without cerebral disease and in 13 patients with intracranial pathological changes. Correlations between the velocity and pressure wave forms at various frequencies of variation were measured with systems analysis techniques. Patients with aneurysmal subarachnoid hemorrhage had high correlations indicating pressure-dependent flow and impaired autoregulation. Patients without cerebral disease had significantly lower correlations (P < 0.01), indicating intact autoregulation. Examples of increasing correlations and correlations at new frequencies emerging as the clinical condition worsened are given. These preliminary examples suggest that the application of systems analysis techniques to velocity and pressure data allow measurement of the temporal nature of cerebral autoregulation.

KW - cerebral aneurysm

KW - cerebral autoregulation

KW - transcranial Doppler ultrasound

UR - http://www.scopus.com/inward/record.url?scp=0025162636&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025162636&partnerID=8YFLogxK

U2 - 10.1227/00006123-199009000-00004

DO - 10.1227/00006123-199009000-00004

M3 - Article

C2 - 2234328

AN - SCOPUS:0025162636

VL - 27

SP - 362

EP - 368

JO - Neurosurgery

JF - Neurosurgery

SN - 0148-396X

IS - 3

ER -