The Genesis stent

A new low-profile stent for use in infants, children, and adults with congenital heart disease

Thomas J. Forbes, Edwin Rodriguez-Cruz, Zahid Amin, Lee N. Benson, Thomas E. Fagan, William E. Hellenbrand, Larry A. Latson, Phillip Moore, Charles E. Mullins, Julie A. Vincent

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Placement of intravascular stents that can reach adult size in infants and smaller children has been limited by the large profile and poor flexibility of currently available stents. In vitro and in vivo testing of the Genesis stent was performed to evaluate crimpability, predeployment flexibility, and radial strength. Comparisons were made to the Palmaz iliac and IntraStent (IS) LD stents. Nine physicians placed 30 Genesis stents in swine pulmonary and systemic arteries to evaluate stent deliverability/crimpability. Two swine were recovered and underwent a second catheterization 8 weeks later, where the stents (n = 8) were reexpanded to maximal size. Angiographic and intravascular ultrasound (IVUS) assessments were performed. In vitro testing revealed the Genesis stent to have superior crimpability, flexibility, and comparable radial strength to the Palmaz iliac stent, and superior crimpability and radial strength and comparable flexibility to the IS LD series. During in vivo testing, the physicians graded the Genesis stent superior to the Palmaz stent regarding crimpability and deliverability, and superior to the IS LD stent in regard to crimpability, and comparable to or superior in deliverability. In the chronic animals, the Genesis stent was expanded up to maximal diameter 8 weeks following implantation. Angiographic and IVUS revealed no fractures no in-stent restenosis. The Genesis stent can be easily delivered through smaller sheaths, which will facilitate their use in infants and smaller children with vascular stenosis.

Original languageEnglish (US)
Pages (from-to)406-414
Number of pages9
JournalCatheterization and Cardiovascular Interventions
Volume59
Issue number3
DOIs
StatePublished - Jul 1 2003
Externally publishedYes

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Stents
Heart Diseases
Swine
Physicians
Catheterization
Pulmonary Artery
Blood Vessels
Pathologic Constriction

Keywords

  • Children
  • Congenital
  • Infants
  • Stenosis
  • Stent

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

The Genesis stent : A new low-profile stent for use in infants, children, and adults with congenital heart disease. / Forbes, Thomas J.; Rodriguez-Cruz, Edwin; Amin, Zahid; Benson, Lee N.; Fagan, Thomas E.; Hellenbrand, William E.; Latson, Larry A.; Moore, Phillip; Mullins, Charles E.; Vincent, Julie A.

In: Catheterization and Cardiovascular Interventions, Vol. 59, No. 3, 01.07.2003, p. 406-414.

Research output: Contribution to journalArticle

Forbes, TJ, Rodriguez-Cruz, E, Amin, Z, Benson, LN, Fagan, TE, Hellenbrand, WE, Latson, LA, Moore, P, Mullins, CE & Vincent, JA 2003, 'The Genesis stent: A new low-profile stent for use in infants, children, and adults with congenital heart disease', Catheterization and Cardiovascular Interventions, vol. 59, no. 3, pp. 406-414. https://doi.org/10.1002/ccd.10547
Forbes, Thomas J. ; Rodriguez-Cruz, Edwin ; Amin, Zahid ; Benson, Lee N. ; Fagan, Thomas E. ; Hellenbrand, William E. ; Latson, Larry A. ; Moore, Phillip ; Mullins, Charles E. ; Vincent, Julie A. / The Genesis stent : A new low-profile stent for use in infants, children, and adults with congenital heart disease. In: Catheterization and Cardiovascular Interventions. 2003 ; Vol. 59, No. 3. pp. 406-414.
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