The genetics of primary open-angle glaucoma: A review

R. Rand Allingham, Yutao Liu, Douglas J. Rhee

Research output: Contribution to journalReview article

176 Scopus citations

Abstract

Glaucoma is the major cause of irreversible blindness worldwide. Primary open-angle glaucoma (POAG), as the most prevalent form of glaucoma, is a complex inherited disorder and affects more than 2 million individuals in the United States. It has become increasingly clear that a host of genetic as well as environmental factors are likely to contribute to the phenotype. A number of chromosomal and genetic associations have been reported for POAG. This review examines what is currently known about the underlying genetic structure, what remains to be learned, and how this may affect our medical management of this major blinding disease.

Original languageEnglish (US)
Pages (from-to)837-844
Number of pages8
JournalExperimental eye research
Volume88
Issue number4
DOIs
StatePublished - Apr 30 2009
Externally publishedYes

Keywords

  • POAG
  • SNP
  • WDR36
  • admixture mapping
  • genetic linkage
  • genetic screening
  • genetics
  • myocilin
  • optineurin
  • whole genome association

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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