The hemodynamic response to chronic hyperinsulinemia in conscious dogs

Michael W Brands, H. Leland Mizelle, Carlo A. Gaillard, Drew A. Hildebrandt, John E. Hall

Research output: Contribution to journalArticle

86 Citations (Scopus)

Abstract

This study describes the hemodynamic effects of chronic hyperinsulinemia in seven normal dogs. Insulin infused at 1 mU/kg/min together with glu­cose at 14 mg/kg/min for 7 days increased fasting plasma insulin concentration approximately six­fold. Plasma glucose concentration was unchanged on day 1 but was below control on day 6. Mean ar­terial pressure decreased from 81 ± 4 mm Hg to 70 ± 3 mm Hg, while cardiac output increased to 30 ± 8% above control by day 7. Total peripheral resistance decreased to 69 ± 5% of control. Urinary sodium ex­cretion was significantly decreased and was accom­ panied by a 22% increase in extracellular fluid vol­ume with no change in blood volume. All parame­ters returned to control levels during the recovery period. These data suggest that, in addition to pro­moting renal sodium retention, insulin may lower blood pressure and increase cardiac output through a peripheral vasodilatory effect.

Original languageEnglish (US)
Pages (from-to)164-168
Number of pages5
JournalAmerican journal of hypertension
Volume4
Issue number2
DOIs
StatePublished - Jan 1 1991
Externally publishedYes

Fingerprint

Hyperinsulinism
Hemodynamics
Dogs
Insulin
Cardiac Output
Glucose
Extracellular Fluid
Blood Volume
Vascular Resistance
Fasting
Arterial Pressure
Sodium
Blood Pressure
Kidney

Keywords

  • Blood volume
  • Cardiac output
  • Hypertension
  • Insulin
  • Sodium excretion

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Brands, M. W., Leland Mizelle, H., Gaillard, C. A., Hildebrandt, D. A., & Hall, J. E. (1991). The hemodynamic response to chronic hyperinsulinemia in conscious dogs. American journal of hypertension, 4(2), 164-168. https://doi.org/10.1093/ajh/4.2.164

The hemodynamic response to chronic hyperinsulinemia in conscious dogs. / Brands, Michael W; Leland Mizelle, H.; Gaillard, Carlo A.; Hildebrandt, Drew A.; Hall, John E.

In: American journal of hypertension, Vol. 4, No. 2, 01.01.1991, p. 164-168.

Research output: Contribution to journalArticle

Brands, MW, Leland Mizelle, H, Gaillard, CA, Hildebrandt, DA & Hall, JE 1991, 'The hemodynamic response to chronic hyperinsulinemia in conscious dogs', American journal of hypertension, vol. 4, no. 2, pp. 164-168. https://doi.org/10.1093/ajh/4.2.164
Brands, Michael W ; Leland Mizelle, H. ; Gaillard, Carlo A. ; Hildebrandt, Drew A. ; Hall, John E. / The hemodynamic response to chronic hyperinsulinemia in conscious dogs. In: American journal of hypertension. 1991 ; Vol. 4, No. 2. pp. 164-168.
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