The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients

Jin Liu, Lingling Bian, Li Ji, Yang Chen, Heng Chen, Yong Gu, Bingqin Ma, Wei Gu, Xinyu Xu, Yun Shi, Jian Wang, Dalong Zhu, Zilin Sun, Jianhua Ma, Hui Jin, Xing Shi, Heng Miao, Bing Xin, Yan Zhu, Zhenwen ZhangRuifang Bu, Lan Xu, Guangde Shi, Wei Tang, Wei Li, Dongmei Zhou, Jun Liang, Xingbo Cheng, Bimin Shi, Jixiang Dong, Ji Hu, Chen Fang, Shao Zhong, Weinan Yu, Weiping Lu, Chenguang Wu, Li Qian, Jiancheng Yu, Jialin Gao, Xiaoqiang Fei, Qingqing Zhang, Xueqin Wang, Shiwei Cui, Jinluo Cheng, Ning Xu, Guofeng Wang, Guoqing Han, Chunrong Xu, Yun Xie, Minmin An, Wei Zhang, Zhixiao Wang, Yun Cai, Qi Fu, Yu Fu, Shuai Zheng, Fan Yang, Qingfang Hu, Hao Dai, Yu Jin, Zheng Zhang, Kuanfeng Xu, Yifan Li, Jie Shen, Hongwen Zhou, Wei He, Xuqin Zheng, Xiao Han, Liping Yu, Jin-Xiong She, Mei Zhang, Tao Yang

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobinA1c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1DM patients (duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus.

Original languageEnglish (US)
Pages (from-to)930-939
Number of pages10
JournalScience China Life Sciences
Volume59
Issue number9
DOIs
StatePublished - Sep 1 2016

Fingerprint

autoantibodies
diabetes
Autoantibodies
antigen
risk factor
insulin-dependent diabetes mellitus
phenotype
Medical problems
Type 1 Diabetes Mellitus
body mass
logistics
allele
tolerance
lipid
zinc
risk factors
acid
Phenotype
thyroid function
Glutamate Decarboxylase

Keywords

  • autoantibodies
  • heterogeneity
  • islet failure
  • type 1 diabetes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Agricultural and Biological Sciences(all)

Cite this

The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients. / Liu, Jin; Bian, Lingling; Ji, Li; Chen, Yang; Chen, Heng; Gu, Yong; Ma, Bingqin; Gu, Wei; Xu, Xinyu; Shi, Yun; Wang, Jian; Zhu, Dalong; Sun, Zilin; Ma, Jianhua; Jin, Hui; Shi, Xing; Miao, Heng; Xin, Bing; Zhu, Yan; Zhang, Zhenwen; Bu, Ruifang; Xu, Lan; Shi, Guangde; Tang, Wei; Li, Wei; Zhou, Dongmei; Liang, Jun; Cheng, Xingbo; Shi, Bimin; Dong, Jixiang; Hu, Ji; Fang, Chen; Zhong, Shao; Yu, Weinan; Lu, Weiping; Wu, Chenguang; Qian, Li; Yu, Jiancheng; Gao, Jialin; Fei, Xiaoqiang; Zhang, Qingqing; Wang, Xueqin; Cui, Shiwei; Cheng, Jinluo; Xu, Ning; Wang, Guofeng; Han, Guoqing; Xu, Chunrong; Xie, Yun; An, Minmin; Zhang, Wei; Wang, Zhixiao; Cai, Yun; Fu, Qi; Fu, Yu; Zheng, Shuai; Yang, Fan; Hu, Qingfang; Dai, Hao; Jin, Yu; Zhang, Zheng; Xu, Kuanfeng; Li, Yifan; Shen, Jie; Zhou, Hongwen; He, Wei; Zheng, Xuqin; Han, Xiao; Yu, Liping; She, Jin-Xiong; Zhang, Mei; Yang, Tao.

In: Science China Life Sciences, Vol. 59, No. 9, 01.09.2016, p. 930-939.

Research output: Contribution to journalArticle

Liu, J, Bian, L, Ji, L, Chen, Y, Chen, H, Gu, Y, Ma, B, Gu, W, Xu, X, Shi, Y, Wang, J, Zhu, D, Sun, Z, Ma, J, Jin, H, Shi, X, Miao, H, Xin, B, Zhu, Y, Zhang, Z, Bu, R, Xu, L, Shi, G, Tang, W, Li, W, Zhou, D, Liang, J, Cheng, X, Shi, B, Dong, J, Hu, J, Fang, C, Zhong, S, Yu, W, Lu, W, Wu, C, Qian, L, Yu, J, Gao, J, Fei, X, Zhang, Q, Wang, X, Cui, S, Cheng, J, Xu, N, Wang, G, Han, G, Xu, C, Xie, Y, An, M, Zhang, W, Wang, Z, Cai, Y, Fu, Q, Fu, Y, Zheng, S, Yang, F, Hu, Q, Dai, H, Jin, Y, Zhang, Z, Xu, K, Li, Y, Shen, J, Zhou, H, He, W, Zheng, X, Han, X, Yu, L, She, J-X, Zhang, M & Yang, T 2016, 'The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients', Science China Life Sciences, vol. 59, no. 9, pp. 930-939. https://doi.org/10.1007/s11427-016-5052-3
Liu, Jin ; Bian, Lingling ; Ji, Li ; Chen, Yang ; Chen, Heng ; Gu, Yong ; Ma, Bingqin ; Gu, Wei ; Xu, Xinyu ; Shi, Yun ; Wang, Jian ; Zhu, Dalong ; Sun, Zilin ; Ma, Jianhua ; Jin, Hui ; Shi, Xing ; Miao, Heng ; Xin, Bing ; Zhu, Yan ; Zhang, Zhenwen ; Bu, Ruifang ; Xu, Lan ; Shi, Guangde ; Tang, Wei ; Li, Wei ; Zhou, Dongmei ; Liang, Jun ; Cheng, Xingbo ; Shi, Bimin ; Dong, Jixiang ; Hu, Ji ; Fang, Chen ; Zhong, Shao ; Yu, Weinan ; Lu, Weiping ; Wu, Chenguang ; Qian, Li ; Yu, Jiancheng ; Gao, Jialin ; Fei, Xiaoqiang ; Zhang, Qingqing ; Wang, Xueqin ; Cui, Shiwei ; Cheng, Jinluo ; Xu, Ning ; Wang, Guofeng ; Han, Guoqing ; Xu, Chunrong ; Xie, Yun ; An, Minmin ; Zhang, Wei ; Wang, Zhixiao ; Cai, Yun ; Fu, Qi ; Fu, Yu ; Zheng, Shuai ; Yang, Fan ; Hu, Qingfang ; Dai, Hao ; Jin, Yu ; Zhang, Zheng ; Xu, Kuanfeng ; Li, Yifan ; Shen, Jie ; Zhou, Hongwen ; He, Wei ; Zheng, Xuqin ; Han, Xiao ; Yu, Liping ; She, Jin-Xiong ; Zhang, Mei ; Yang, Tao. / The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients. In: Science China Life Sciences. 2016 ; Vol. 59, No. 9. pp. 930-939.
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