The Immune Landscape of Cancer

The Cancer Genome Atlas Research Network

Research output: Contribution to journalArticle

245 Citations (Scopus)

Abstract

We performed an extensive immunogenomic analysis of more than 10,000 tumors comprising 33 diverse cancer types by utilizing data compiled by TCGA. Across cancer types, we identified six immune subtypes—wound healing, IFN-γ dominant, inflammatory, lymphocyte depleted, immunologically quiet, and TGF-β dominant—characterized by differences in macrophage or lymphocyte signatures, Th1:Th2 cell ratio, extent of intratumoral heterogeneity, aneuploidy, extent of neoantigen load, overall cell proliferation, expression of immunomodulatory genes, and prognosis. Specific driver mutations correlated with lower (CTNNB1, NRAS, or IDH1) or higher (BRAF, TP53, or CASP8) leukocyte levels across all cancers. Multiple control modalities of the intracellular and extracellular networks (transcription, microRNAs, copy number, and epigenetic processes) were involved in tumor-immune cell interactions, both across and within immune subtypes. Our immunogenomics pipeline to characterize these heterogeneous tumors and the resulting data are intended to serve as a resource for future targeted studies to further advance the field. Thorsson et al. present immunogenomics analyses of more than 10,000 tumors, identifying six immune subtypes that encompass multiple cancer types and are hypothesized to define immune response patterns impacting prognosis. This work provides a resource for understanding tumor-immune interactions, with implications for identifying ways to advance research on immunotherapy.

Original languageEnglish (US)
Pages (from-to)812-830.e14
JournalImmunity
Volume48
Issue number4
DOIs
StatePublished - Apr 17 2018

Fingerprint

Neoplasms
Genetic Epigenesis
Lymphocytes
Th2 Cells
Th1 Cells
Aneuploidy
MicroRNAs
Cell Communication
Immunotherapy
Leukocytes
Macrophages
Cell Proliferation
Gene Expression
Mutation
Research

Keywords

  • cancer genomics
  • immune subtypes
  • immuno-oncology
  • immunomodulatory
  • immunotherapy
  • integrative network analysis
  • tumor immunology
  • tumor microenvironment

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Cite this

The Cancer Genome Atlas Research Network (2018). The Immune Landscape of Cancer. Immunity, 48(4), 812-830.e14. https://doi.org/10.1016/j.immuni.2018.03.023

The Immune Landscape of Cancer. / The Cancer Genome Atlas Research Network.

In: Immunity, Vol. 48, No. 4, 17.04.2018, p. 812-830.e14.

Research output: Contribution to journalArticle

The Cancer Genome Atlas Research Network 2018, 'The Immune Landscape of Cancer', Immunity, vol. 48, no. 4, pp. 812-830.e14. https://doi.org/10.1016/j.immuni.2018.03.023
The Cancer Genome Atlas Research Network. The Immune Landscape of Cancer. Immunity. 2018 Apr 17;48(4):812-830.e14. https://doi.org/10.1016/j.immuni.2018.03.023
The Cancer Genome Atlas Research Network. / The Immune Landscape of Cancer. In: Immunity. 2018 ; Vol. 48, No. 4. pp. 812-830.e14.
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KW - cancer genomics

KW - immune subtypes

KW - immuno-oncology

KW - immunomodulatory

KW - immunotherapy

KW - integrative network analysis

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