The influence of cervical sympathetic neurons on parathyroid hormone and calcitonin release in the rat: Independence of pineal mediation

Javier E. Stern, Ana I. Esquifino, Manuel García Bonacho, Daniel P. Cardinali

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The objective of this study was to evaluate the involvement of the pineal gland in modulation of parathyroid hormone (PTH) and calcitonin release found in rats after changes in activity of cervical sympathetic nerves. The response of serum PTH to a hypocalcemia produced by EDTA injection, and of serum calcitonin to a hypercalcemia produced by administering calcium chloride, were studied in rats at the time of the wallerian degeneration of regional sympathetic nerves (i.e., 16 hr after superior cervical ganglionectomy, SCGx). Rats received a pinealectomy or its sham-operation 4 days before SCGx. During wallerian degeneration of nerves after SCGx, a higher hypocalcemia and a lower PTH response were found as compared to sham-SCGx rats, regardless of whether the pineal gland was present or not. When the response of calcitonin to a bolus injection of calcium chloride was assessed, rats subjected to SCGx 16 hr earlier showed a depressed calcitonin release, which was also unaffected after pinealectomy. To a similar extent in pinealectomized and sham-pinealectomized rats, a mild stress given by the subcutaneous injection of turpentine oil brought about a greater hypocalcemia after EDTA, concomitantly with a higher PTH secretory response. In turpentine oil-injected rats, the rise of serum calcitonin was significantly greater than that of vehicle-treated rats, regardless of pineal presence. The results further indicate that cervical autonomic nerves constitute a pathway through which the brain modulates calcium homeostasis and do not support the participation of the pineal gland in short term changes of PTH or calcitonin release.

Original languageEnglish (US)
Pages (from-to)9-15
Number of pages7
JournalJournal of Pineal Research
Volume22
Issue number1
DOIs
StatePublished - Jan 1 1997

Fingerprint

Calcitonin
Parathyroid Hormone
Neurons
Pineal Gland
Hypocalcemia
Turpentine
Wallerian Degeneration
Calcium Chloride
Edetic Acid
Serum
Ganglionectomy
Autonomic Pathways
Injections
Hypercalcemia
Subcutaneous Injections
Homeostasis
Calcium
Brain

Keywords

  • Calcitonin
  • Calcium homeostasis
  • Parathyroid hormone
  • Pineal gland
  • Stress
  • Superior cervical ganglion

ASJC Scopus subject areas

  • Endocrinology

Cite this

The influence of cervical sympathetic neurons on parathyroid hormone and calcitonin release in the rat : Independence of pineal mediation. / Stern, Javier E.; Esquifino, Ana I.; Bonacho, Manuel García; Cardinali, Daniel P.

In: Journal of Pineal Research, Vol. 22, No. 1, 01.01.1997, p. 9-15.

Research output: Contribution to journalArticle

Stern, Javier E. ; Esquifino, Ana I. ; Bonacho, Manuel García ; Cardinali, Daniel P. / The influence of cervical sympathetic neurons on parathyroid hormone and calcitonin release in the rat : Independence of pineal mediation. In: Journal of Pineal Research. 1997 ; Vol. 22, No. 1. pp. 9-15.
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