The influence of hepatic function on prostate cancer outcomes after radical prostatectomy

L. L. Bañez, R. M. Loftis, S. J. Freedland, J. C. Presti, W. J. Aronson, C. L. Amling, C. J. Kane, M. K. Terris

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Prostate growth is dependent on circulating androgens, which can be influenced by hepatic function. Liver disease has been suggested to influence prostate cancer (CaP) incidence. However, the effect of hepatic function on CaP outcomes has not been investigated. A total of 1181 patients who underwent radical prostatectomy (RP) between 1988 and 2008 at four Veterans Affairs hospitals that comprise the Shared Equal Access Regional Cancer Hospital database and had available liver function test (LFT) data were included in the study. Independent associations of LFTs with unfavorable pathological features and biochemical recurrence were determined using logistic and Cox regression analyses. Serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) levels were elevated in 8.2 and 4.4% of patients, respectively. After controlling for CaP features, logistic regression revealed a significant association between SGOT levels and pathological Gleason sum ≥7(4+3) cancer (odds ratio=2.12; 95% confidence interval=1.11-4.05; P=0.02). Mild hepatic dysfunction was significantly associated with adverse CaP grade, but was not significantly associated with other adverse pathological features or biochemical recurrence in a cohort of men undergoing RP. The effect of moderate-to-severe liver disease on disease outcomes in CaP patients managed non-surgically remains to be investigated.

Original languageEnglish (US)
Pages (from-to)173-177
Number of pages5
JournalProstate Cancer and Prostatic Diseases
Volume13
Issue number2
DOIs
StatePublished - Jun 1 2010

Fingerprint

Prostatectomy
Prostatic Neoplasms
Aspartate Aminotransferases
Liver Diseases
Liver
Logistic Models
Veterans Hospitals
Cancer Care Facilities
Recurrence
Liver Function Tests
Alanine Transaminase
Androgens
Prostate
Odds Ratio
Regression Analysis
Databases
Confidence Intervals
Incidence
Growth
Serum

Keywords

  • Liver function tests
  • PSA recurrence
  • Pathology
  • Prostate neoplasm
  • Radical prostatectomy
  • Staging

ASJC Scopus subject areas

  • Oncology
  • Urology
  • Cancer Research

Cite this

Bañez, L. L., Loftis, R. M., Freedland, S. J., Presti, J. C., Aronson, W. J., Amling, C. L., ... Terris, M. K. (2010). The influence of hepatic function on prostate cancer outcomes after radical prostatectomy. Prostate Cancer and Prostatic Diseases, 13(2), 173-177. https://doi.org/10.1038/pcan.2010.3

The influence of hepatic function on prostate cancer outcomes after radical prostatectomy. / Bañez, L. L.; Loftis, R. M.; Freedland, S. J.; Presti, J. C.; Aronson, W. J.; Amling, C. L.; Kane, C. J.; Terris, M. K.

In: Prostate Cancer and Prostatic Diseases, Vol. 13, No. 2, 01.06.2010, p. 173-177.

Research output: Contribution to journalArticle

Bañez, LL, Loftis, RM, Freedland, SJ, Presti, JC, Aronson, WJ, Amling, CL, Kane, CJ & Terris, MK 2010, 'The influence of hepatic function on prostate cancer outcomes after radical prostatectomy', Prostate Cancer and Prostatic Diseases, vol. 13, no. 2, pp. 173-177. https://doi.org/10.1038/pcan.2010.3
Bañez, L. L. ; Loftis, R. M. ; Freedland, S. J. ; Presti, J. C. ; Aronson, W. J. ; Amling, C. L. ; Kane, C. J. ; Terris, M. K. / The influence of hepatic function on prostate cancer outcomes after radical prostatectomy. In: Prostate Cancer and Prostatic Diseases. 2010 ; Vol. 13, No. 2. pp. 173-177.
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