The influence of vitamin D supplementation on local and systemic inflammatory markers in periodontitis patients: A pilot study

Mohamed M. Meghil, Lance Hutchens, Anas Raed, Neha A. Multani, Mythilypriya Rajendran, Haidong Zhu, Stephen Warwick Looney, Mahmoud Elashiry, Roger Mauricio Arce Munoz, Mark E. Peacock, Yanbin Dong, Christopher W Cutler

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objectives: Vitamin D deficiency/insufficiency is a worldwide public health issue that has been linked to numerous inflammatory disorders, including periodontitis. There is increasing support for a role for adequate vitamin D levels in overall health. Populations with darker skin color have a higher prevalence of vitamin D deficiency/insufficiency and periodontitis. The purpose of this small pilot study was to investigate the influence of 12 weeks of 25(OH)D vitamin D supplementation (VDS) on mediators of systemic inflammation in dark-skinned, periodontitis patients. Materials and Methods: A total of 23 patients with moderate to severe periodontitis were randomly assigned to the vitamin D group or placebo group and received intensive single visit scaling and root planning to elicit a systemic inflammatory response. Results: Vitamin D supplementation increased serum 25(OH)D levels approximately 2-fold over baseline levels; moreover, VDS group had reduced peripheral blood CD3 and CD3+CD8+ cytotoxic T lymphocyte (CTLs) counts and reduced pro-inflammatory salivary cytokines. In contrast, VDS group had higher levels of the autophagy-related proteins and other proteins crucial for anti-microbial autophagy in whole blood PBMCs. Conclusion: In conclusion, VDS has multiple benefits for reducing systemic inflammation and promoting induction of autophagy-related proteins related to anti-microbial functions.

Original languageEnglish (US)
Pages (from-to)1403-1413
Number of pages11
JournalOral Diseases
Volume25
Issue number5
DOIs
StatePublished - Jul 1 2019

Fingerprint

Periodontitis
Vitamin D
Vitamin D Deficiency
Dental Scaling
Skin Pigmentation
Inflammation Mediators
Autophagy
Lymphocyte Count
Cytotoxic T-Lymphocytes
Public Health
Placebos
Cytokines
Inflammation
Health
Serum
Population
Proteins

Keywords

  • autophagy
  • immunity
  • periodontitis
  • saliva
  • vitamin D

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Dentistry(all)

Cite this

The influence of vitamin D supplementation on local and systemic inflammatory markers in periodontitis patients : A pilot study. / Meghil, Mohamed M.; Hutchens, Lance; Raed, Anas; Multani, Neha A.; Rajendran, Mythilypriya; Zhu, Haidong; Looney, Stephen Warwick; Elashiry, Mahmoud; Arce Munoz, Roger Mauricio; Peacock, Mark E.; Dong, Yanbin; Cutler, Christopher W.

In: Oral Diseases, Vol. 25, No. 5, 01.07.2019, p. 1403-1413.

Research output: Contribution to journalArticle

@article{489a5d6d15b447059db66021e67cb833,
title = "The influence of vitamin D supplementation on local and systemic inflammatory markers in periodontitis patients: A pilot study",
abstract = "Objectives: Vitamin D deficiency/insufficiency is a worldwide public health issue that has been linked to numerous inflammatory disorders, including periodontitis. There is increasing support for a role for adequate vitamin D levels in overall health. Populations with darker skin color have a higher prevalence of vitamin D deficiency/insufficiency and periodontitis. The purpose of this small pilot study was to investigate the influence of 12 weeks of 25(OH)D vitamin D supplementation (VDS) on mediators of systemic inflammation in dark-skinned, periodontitis patients. Materials and Methods: A total of 23 patients with moderate to severe periodontitis were randomly assigned to the vitamin D group or placebo group and received intensive single visit scaling and root planning to elicit a systemic inflammatory response. Results: Vitamin D supplementation increased serum 25(OH)D levels approximately 2-fold over baseline levels; moreover, VDS group had reduced peripheral blood CD3 and CD3+CD8+ cytotoxic T lymphocyte (CTLs) counts and reduced pro-inflammatory salivary cytokines. In contrast, VDS group had higher levels of the autophagy-related proteins and other proteins crucial for anti-microbial autophagy in whole blood PBMCs. Conclusion: In conclusion, VDS has multiple benefits for reducing systemic inflammation and promoting induction of autophagy-related proteins related to anti-microbial functions.",
keywords = "autophagy, immunity, periodontitis, saliva, vitamin D",
author = "Meghil, {Mohamed M.} and Lance Hutchens and Anas Raed and Multani, {Neha A.} and Mythilypriya Rajendran and Haidong Zhu and Looney, {Stephen Warwick} and Mahmoud Elashiry and {Arce Munoz}, {Roger Mauricio} and Peacock, {Mark E.} and Yanbin Dong and Cutler, {Christopher W}",
year = "2019",
month = "7",
day = "1",
doi = "10.1111/odi.13097",
language = "English (US)",
volume = "25",
pages = "1403--1413",
journal = "Oral Diseases",
issn = "1354-523X",
publisher = "Wiley-Blackwell",
number = "5",

}

TY - JOUR

T1 - The influence of vitamin D supplementation on local and systemic inflammatory markers in periodontitis patients

T2 - A pilot study

AU - Meghil, Mohamed M.

AU - Hutchens, Lance

AU - Raed, Anas

AU - Multani, Neha A.

AU - Rajendran, Mythilypriya

AU - Zhu, Haidong

AU - Looney, Stephen Warwick

AU - Elashiry, Mahmoud

AU - Arce Munoz, Roger Mauricio

AU - Peacock, Mark E.

AU - Dong, Yanbin

AU - Cutler, Christopher W

PY - 2019/7/1

Y1 - 2019/7/1

N2 - Objectives: Vitamin D deficiency/insufficiency is a worldwide public health issue that has been linked to numerous inflammatory disorders, including periodontitis. There is increasing support for a role for adequate vitamin D levels in overall health. Populations with darker skin color have a higher prevalence of vitamin D deficiency/insufficiency and periodontitis. The purpose of this small pilot study was to investigate the influence of 12 weeks of 25(OH)D vitamin D supplementation (VDS) on mediators of systemic inflammation in dark-skinned, periodontitis patients. Materials and Methods: A total of 23 patients with moderate to severe periodontitis were randomly assigned to the vitamin D group or placebo group and received intensive single visit scaling and root planning to elicit a systemic inflammatory response. Results: Vitamin D supplementation increased serum 25(OH)D levels approximately 2-fold over baseline levels; moreover, VDS group had reduced peripheral blood CD3 and CD3+CD8+ cytotoxic T lymphocyte (CTLs) counts and reduced pro-inflammatory salivary cytokines. In contrast, VDS group had higher levels of the autophagy-related proteins and other proteins crucial for anti-microbial autophagy in whole blood PBMCs. Conclusion: In conclusion, VDS has multiple benefits for reducing systemic inflammation and promoting induction of autophagy-related proteins related to anti-microbial functions.

AB - Objectives: Vitamin D deficiency/insufficiency is a worldwide public health issue that has been linked to numerous inflammatory disorders, including periodontitis. There is increasing support for a role for adequate vitamin D levels in overall health. Populations with darker skin color have a higher prevalence of vitamin D deficiency/insufficiency and periodontitis. The purpose of this small pilot study was to investigate the influence of 12 weeks of 25(OH)D vitamin D supplementation (VDS) on mediators of systemic inflammation in dark-skinned, periodontitis patients. Materials and Methods: A total of 23 patients with moderate to severe periodontitis were randomly assigned to the vitamin D group or placebo group and received intensive single visit scaling and root planning to elicit a systemic inflammatory response. Results: Vitamin D supplementation increased serum 25(OH)D levels approximately 2-fold over baseline levels; moreover, VDS group had reduced peripheral blood CD3 and CD3+CD8+ cytotoxic T lymphocyte (CTLs) counts and reduced pro-inflammatory salivary cytokines. In contrast, VDS group had higher levels of the autophagy-related proteins and other proteins crucial for anti-microbial autophagy in whole blood PBMCs. Conclusion: In conclusion, VDS has multiple benefits for reducing systemic inflammation and promoting induction of autophagy-related proteins related to anti-microbial functions.

KW - autophagy

KW - immunity

KW - periodontitis

KW - saliva

KW - vitamin D

UR - http://www.scopus.com/inward/record.url?scp=85064663273&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85064663273&partnerID=8YFLogxK

U2 - 10.1111/odi.13097

DO - 10.1111/odi.13097

M3 - Article

C2 - 30912231

AN - SCOPUS:85064663273

VL - 25

SP - 1403

EP - 1413

JO - Oral Diseases

JF - Oral Diseases

SN - 1354-523X

IS - 5

ER -