The influence of vitamin D supplementation on local and systemic inflammatory markers in periodontitis patients: A pilot study

Mohamed M. Meghil, Lance Hutchens, Anas Raed, Neha A. Multani, Mythilypriya Rajendran, Haidong Zhu, Stephen Looney, Mahmoud Elashiry, Roger M. Arce, Mark E. Peacock, Yanbin Dong, Christopher W. Cutler

Research output: Contribution to journalArticle

5 Scopus citations


Objectives: Vitamin D deficiency/insufficiency is a worldwide public health issue that has been linked to numerous inflammatory disorders, including periodontitis. There is increasing support for a role for adequate vitamin D levels in overall health. Populations with darker skin color have a higher prevalence of vitamin D deficiency/insufficiency and periodontitis. The purpose of this small pilot study was to investigate the influence of 12 weeks of 25(OH)D vitamin D supplementation (VDS) on mediators of systemic inflammation in dark-skinned, periodontitis patients. Materials and Methods: A total of 23 patients with moderate to severe periodontitis were randomly assigned to the vitamin D group or placebo group and received intensive single visit scaling and root planning to elicit a systemic inflammatory response. Results: Vitamin D supplementation increased serum 25(OH)D levels approximately 2-fold over baseline levels; moreover, VDS group had reduced peripheral blood CD3 and CD3+CD8+ cytotoxic T lymphocyte (CTLs) counts and reduced pro-inflammatory salivary cytokines. In contrast, VDS group had higher levels of the autophagy-related proteins and other proteins crucial for anti-microbial autophagy in whole blood PBMCs. Conclusion: In conclusion, VDS has multiple benefits for reducing systemic inflammation and promoting induction of autophagy-related proteins related to anti-microbial functions.

Original languageEnglish (US)
Pages (from-to)1403-1413
Number of pages11
JournalOral Diseases
Issue number5
Publication statusPublished - Jul 2019



  • autophagy
  • immunity
  • periodontitis
  • saliva
  • vitamin D

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Dentistry(all)

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