@article{b2f2f73931b64f93b6a456da6cbf7648,
title = "The interaction between vitamin D receptor polymorphisms and sun exposure around time of diagnosis influences melanoma survival",
abstract = "Evidence on the relationship between the vitamin D pathway and outcomes in melanoma is growing, although it is not always clear. We investigated the impact of measured levels of sun exposure at diagnosis on associations of vitamin D receptor gene (VDR) polymorphisms and melanoma death in 3336 incident primary melanoma cases. Interactions between six SNPs and a common 3′-end haplotype were significant (p <.05). These SNPs, and a haplotype, had a statistically significant association with survival among subjects exposed to high UVB in multivariable regression models and exerted their effect in the opposite direction among those with low UVB. SNPs rs1544410/BsmI and rs731236/TaqI remained significant after adjustment for multiple testing. These results suggest that the association between VDR and melanoma-specific survival is modified by sun exposure around diagnosis, and require validation in an independent study. Whether the observed effects are dependent or independent of vitamin D activation remains to be determined.",
keywords = "SNP, UVB, exposure, haplotype, interaction, melanoma, polymorphism, survival, vitamin D receptor",
author = "{The GEM Study Group} and Irene Orlow and Yang Shi and Kanetsky, {Peter A.} and Thomas, {Nancy E.} and Li Luo and Sergio Corrales-Guerrero and Cust, {Anne E.} and Lidia Sacchetto and Roberto Zanetti and Stefano Rosso and Armstrong, {Bruce K.} and Terence Dwyer and Alison Venn and Gallagher, {Richard P.} and Gruber, {Stephen B.} and Marrett, {Loraine D.} and Hoda Anton-Culver and Klaus Busam and Begg, {Colin B.} and Marianne Berwick and Pampa Roy and Himali Patel and Sarah Yoo and Anne Reiner and Susan Paine and Anne Kricker and Paul Tucker and Lynn From and Ollila, {David W.} and Groben, {Pamela A.} and Rebbeck, {Timothy R.} and Taylor, {Julia Lee} and Sasha Madronich",
note = "Funding Information: This work was supported by the National Cancer Institute [UO183180, CA112524, and CA112524-S1 to M.B.] [CA112243 and CA112243-05S1 to N.T.] [P30-CA008748 to MSK]. The MSK Sequenom facility was supported by the Anbinder Fund. The study was conducted by the GEM Study Group. Coordinating Center, Memorial Sloan Kettering Cancer Center, New York, NY (USA): Marianne Berwick (PI, currently at the University of New Mexico), Colin Begg, Ph.D. (co-PI), Irene Orlow, Ph.D., M.S. (co-Investigator), Klaus J. Busam, M.D. (Dermatopathologist), Pampa Roy, Ph.D. (Senior Laboratory Technician), Himali Patel, M.S. (Senior Laboratory Technician), Sarah Yoo, M.S. (Senior Laboratory Technician), Anne Reiner, M.S. (Biostatistician); University of New Mexico, Albuquerque: Marianne Berwick, M.P.H., Ph.D. (PI), Li Luo, Ph.D. (Biostatistician), Susan Paine, M.P.H. (Data Manager). Study Centers: The University of Sydney and The Cancer Council New South Wales, Sydney, Australia: Anne Cust, Ph.D. (PI), Bruce K. Armstrong M.D. Ph.D. (former PI), Anne Kricker Ph.D., (former Co-PI) Menzies Institute for Medical Research University of Tasmania, Hobart, Australia: Alison Venn (current PI), Terence Dwyer (PI, currently at University of Oxford, United Kingdom), Paul Tucker (Dermatopathologist) British Columbia Cancer Research Centre, Vancouver, Canada: Richard P. Gallagher, M.A. (PI), Cancer Care Ontario, Toronto, Canada: Loraine D. Marrett, Ph.D. (PI), Lynn From, M.D. (Dermatopathologist) CPO, Center for Cancer Prevention, Torino, Italy: Roberto Zanetti, M.D (PI), Stefano Rosso, M.D., M.S. (co-PI) University of California, Irvine, CA: Hoda Anton-Culver, Ph.D. (PI) University of Michigan, Ann Arbor, MI: University of Michigan, Ann Arbor: Stephen B. Gruber, M.D., M.P.H., Ph.D. (PI, currently at University of Southern California, Los Angeles, CA), University of North Carolina, Chapel Hill, NC: Nancy E. Thomas, M.D., Ph.D. (PI), David W. Ollila, M.D. (co-Investigator), Pamela A. Groben, M.D. (Dermatopathologist) University of Pennsylvania, Philadelphia, PA: Timothy R. Rebbeck, Ph.D. (former PI), Peter A. Kanetsky, M.P.H., Ph.D. (PI, currently at H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida) UV data consultants: Julia Lee Taylor, Ph.D. and Sasha Madronich, Ph.D., National Centre for Atmospheric Research, Boulder, CO. Funding Information: National Cancer Institute, Grant/Award Number: CA112243, CA112243-S1, CA112524, CA112524-S1, CCSG award P30- CA008748 and UO183180; Anbinder Fund Funding Information: This work was supported by the National Cancer Institute [UO183180, CA112524, and CA112524-S1 to M.B.] [CA112243 and CA112243-05S1 to N.T.] [P30-CA008748 to MSK]. The MSK Sequenom facility was supported by the Anbinder Fund. The study was conducted by the GEM Study Group. Coordinating Center, Memorial Sloan Kettering Cancer Center, New York, NY (USA): Marianne Berwick (PI, currently at the University of New Mexico), Colin Begg, Ph.D. (co-PI), Irene Orlow, Ph.D., M.S. (coInvestigator), Klaus J. Busam, M.D. (Dermatopathologist), Pampa Roy, Ph.D. (Senior Laboratory Technician), Himali Patel, M.S. (Senior Laboratory Technician), Sarah Yoo, M.S. (Senior Laboratory Technician), Anne Reiner, M.S. (Biostatistician); University of New Mexico, Albuquerque: Marianne Berwick, M.P.H., Ph.D. (PI), Li Luo, Ph.D. (Biostatistician), Susan Paine, M.P.H. (Data Manager). Study Centers: The University of Sydney and The Cancer Council New South Wales, Sydney, Australia: Anne Cust, Ph.D. (PI), Bruce K. Armstrong M.D. Ph.D. (former PI), Anne Kricker Ph.D., (former Co-PI) Menzies Institute for Medical Research University of Tasmania, Hobart, Australia: Alison Venn (current PI), Terence Dwyer (PI, currently at University of Oxford, United Kingdom), Paul Tucker (Dermatopathologist) British Columbia Cancer Research Centre, Vancouver, Canada: Richard P. Gallagher, M.A. (PI), Cancer Care Ontario, Toronto, Canada: Loraine D. Marrett, Ph.D. (PI), Lynn From, M.D. (Dermatopathologist) CPO, Center for Cancer Prevention, Torino, Italy: Roberto Zanetti, M.D (PI), Stefano Rosso, M.D., M.S. (co-PI) University of California, Irvine, CA: Hoda Anton-Culver, Ph.D. (PI) University of Michigan, Ann Arbor, MI: University of Michigan, Ann Arbor: Stephen B. Gruber, M.D., M.P.H., Ph.D. (PI, currently at University of Southern California, Los Angeles, CA), University of North Carolina, Chapel Hill, NC: Nancy E. Thomas, M.D., Ph.D. (PI), David W. Ollila, M.D. (co-Investigator), Pamela A. Groben, M.D. (Dermatopathologist) University of Pennsylvania, Philadelphia, PA: Timothy R. Rebbeck, Ph.D. (former PI), Peter A. Kanetsky, M.P.H., Ph.D. (PI, currently at H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida) UV data consultants: Julia Lee Taylor, Ph.D. and Sasha Madronich, Ph.D., National Centre for Atmospheric Research, Boulder, CO. Publisher Copyright: {\textcopyright} 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd",
year = "2018",
month = mar,
doi = "10.1111/pcmr.12653",
language = "English (US)",
volume = "31",
pages = "287--296",
journal = "Pigment Cell and Melanoma Research",
issn = "1755-1471",
publisher = "Wiley-Blackwell",
number = "2",
}