The interaction between vitamin D receptor polymorphisms and sun exposure around time of diagnosis influences melanoma survival

The GEM Study Group

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Evidence on the relationship between the vitamin D pathway and outcomes in melanoma is growing, although it is not always clear. We investigated the impact of measured levels of sun exposure at diagnosis on associations of vitamin D receptor gene (VDR) polymorphisms and melanoma death in 3336 incident primary melanoma cases. Interactions between six SNPs and a common 3′-end haplotype were significant (p <.05). These SNPs, and a haplotype, had a statistically significant association with survival among subjects exposed to high UVB in multivariable regression models and exerted their effect in the opposite direction among those with low UVB. SNPs rs1544410/BsmI and rs731236/TaqI remained significant after adjustment for multiple testing. These results suggest that the association between VDR and melanoma-specific survival is modified by sun exposure around diagnosis, and require validation in an independent study. Whether the observed effects are dependent or independent of vitamin D activation remains to be determined.

Original languageEnglish (US)
Pages (from-to)287-296
Number of pages10
JournalPigment Cell and Melanoma Research
Volume31
Issue number2
DOIs
StatePublished - Mar 2018

Fingerprint

Calcitriol Receptors
Solar System
Polymorphism
Vitamin D
Sun
Melanoma
Genes
Association reactions
Single Nucleotide Polymorphism
Haplotypes
Chemical activation
Testing
Direction compound

Keywords

  • SNP
  • UVB
  • exposure
  • haplotype
  • interaction
  • melanoma
  • polymorphism
  • survival
  • vitamin D receptor

ASJC Scopus subject areas

  • Oncology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Dermatology

Cite this

The interaction between vitamin D receptor polymorphisms and sun exposure around time of diagnosis influences melanoma survival. / The GEM Study Group.

In: Pigment Cell and Melanoma Research, Vol. 31, No. 2, 03.2018, p. 287-296.

Research output: Contribution to journalArticle

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abstract = "Evidence on the relationship between the vitamin D pathway and outcomes in melanoma is growing, although it is not always clear. We investigated the impact of measured levels of sun exposure at diagnosis on associations of vitamin D receptor gene (VDR) polymorphisms and melanoma death in 3336 incident primary melanoma cases. Interactions between six SNPs and a common 3′-end haplotype were significant (p <.05). These SNPs, and a haplotype, had a statistically significant association with survival among subjects exposed to high UVB in multivariable regression models and exerted their effect in the opposite direction among those with low UVB. SNPs rs1544410/BsmI and rs731236/TaqI remained significant after adjustment for multiple testing. These results suggest that the association between VDR and melanoma-specific survival is modified by sun exposure around diagnosis, and require validation in an independent study. Whether the observed effects are dependent or independent of vitamin D activation remains to be determined.",
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