The interaction of mercury with cadmium and zinc in mammalian embryonic development

Research output: Contribution to journalArticle

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Abstract

Mercuric acetate (Hg) together with either cadmium sulfate (Cd) or zinc sulfate (Zn) were administered intravenously to pregnant golden hamsters on the eighth gestation day in order to study their effects upon embryogenesis. Upon sacrifice on either Day 12 or 14 of gestation, the resorption and malformation rates were determined and all living embryos were scrutinized for gross malformations. Several generalizations can be made regarding these experiments. (1) The detrimental effects of the Hg + Cd combinations are much more severe than those of the Hg + Zn combinations. (2) With both combinations the severity of the embryotoxicity depends upon the method by which the metals are introduced and to some extent upon the dosage level of the Hg. (3) The protective value of Zn against the embryopathic effects of Hg is also determined by the method of administration of the two metals. (4) Both the types of malformations observed after the administration of either Cd or Hg alone are detected in the animals treated with Hg + Cd. (5) The Hg + Zn combinations produce only a few miscellaneous malformations. The results are briefly correlated with known biological actions of Cd, Hg, and Zn.

Original languageEnglish (US)
Pages (from-to)95-105
Number of pages11
JournalEnvironmental Research
Volume6
Issue number1
DOIs
StatePublished - Jan 1 1973
Externally publishedYes

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embryonic development
Mercury
Cadmium
Embryonic Development
Zinc
cadmium
Metals
zinc
Zinc Sulfate
Pregnancy
Mesocricetus
pregnancy
Animals
Embryonic Structures
sulfate
resorption
metal
embryo
acetate
Experiments

ASJC Scopus subject areas

  • Biochemistry
  • Environmental Science(all)

Cite this

The interaction of mercury with cadmium and zinc in mammalian embryonic development. / Gale, Thomas F.

In: Environmental Research, Vol. 6, No. 1, 01.01.1973, p. 95-105.

Research output: Contribution to journalArticle

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