The interplay between Angiotensin II, TLR4 and hypertension

Vinicia Campana Biancardi, Gisele Facholi Bomfim, Wagner Luis Reis, Sarah Al-Gassimi, Kenia Pedrosa Nunes

Research output: Contribution to journalReview article

25 Citations (Scopus)

Abstract

Hypertension is a multifactorial disease. Although a number of different underlying mechanisms have been learned from the various experimental models of the disease, hypertension still poses challenges for treatment. Angiotensin II plays an unquestionable role in blood pressure regulation acting through central and peripheral mechanisms. During hypertension, dysregulation of the Renin-Angiotensin System is associated with increased expression of pro-inflammatory cytokines and reactive oxygen species causing kidney damage, endothelial dysfunction, and increase in sympathetic activity, among other damages, eventually leading to decline in organ function. Recent studies have shown that these effects involve both the innate and the adaptive immune response. The contribution of adaptive immune responses involving different lymphocyte populations in various models of hypertension has been extensively studied. However, the involvement of the innate immunity mediating inflammation in hypertension is still not well understood. The innate and adaptive immune systems intimately interact with one another and are essential to an effectively functioning of the immune response; hence, the importance of a better understanding of the underlying mechanisms mediating innate immune system during hypertension. In this review, we aim to discuss mechanisms linking Angiotensin II and the innate immune system, in the pathogenesis of hypertension. The newest research investigating Angiotensin II triggering toll like receptor 4 activation in the kidney, vasculature and central nervous system contributing to hypertension will be discussed. Understanding the role of the innate immune system in the development of hypertension may bring to light new insights necessary to improve hypertension management.

Original languageEnglish (US)
Pages (from-to)88-96
Number of pages9
JournalPharmacological Research
Volume120
DOIs
StatePublished - Jun 1 2017

Fingerprint

Angiotensin II
Hypertension
Immune System
Adaptive Immunity
Innate Immunity
Kidney
Toll-Like Receptor 4
Renin-Angiotensin System
Reactive Oxygen Species
Theoretical Models
Central Nervous System
Lymphocytes
Cytokines
Blood Pressure
Inflammation
Research

Keywords

  • Angiotensin II
  • Central nervous system
  • Hypertension
  • Innate immune system
  • Kidney
  • Vasculature

ASJC Scopus subject areas

  • Pharmacology

Cite this

Biancardi, V. C., Bomfim, G. F., Reis, W. L., Al-Gassimi, S., & Nunes, K. P. (2017). The interplay between Angiotensin II, TLR4 and hypertension. Pharmacological Research, 120, 88-96. https://doi.org/10.1016/j.phrs.2017.03.017

The interplay between Angiotensin II, TLR4 and hypertension. / Biancardi, Vinicia Campana; Bomfim, Gisele Facholi; Reis, Wagner Luis; Al-Gassimi, Sarah; Nunes, Kenia Pedrosa.

In: Pharmacological Research, Vol. 120, 01.06.2017, p. 88-96.

Research output: Contribution to journalReview article

Biancardi, VC, Bomfim, GF, Reis, WL, Al-Gassimi, S & Nunes, KP 2017, 'The interplay between Angiotensin II, TLR4 and hypertension', Pharmacological Research, vol. 120, pp. 88-96. https://doi.org/10.1016/j.phrs.2017.03.017
Biancardi VC, Bomfim GF, Reis WL, Al-Gassimi S, Nunes KP. The interplay between Angiotensin II, TLR4 and hypertension. Pharmacological Research. 2017 Jun 1;120:88-96. https://doi.org/10.1016/j.phrs.2017.03.017
Biancardi, Vinicia Campana ; Bomfim, Gisele Facholi ; Reis, Wagner Luis ; Al-Gassimi, Sarah ; Nunes, Kenia Pedrosa. / The interplay between Angiotensin II, TLR4 and hypertension. In: Pharmacological Research. 2017 ; Vol. 120. pp. 88-96.
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