The interplay between Src family kinases and receptor tyrosine kinases

Paul A. Bromann, Hasan Korkaya, Sara A. Courtneidge

Research output: Contribution to journalReview article

353 Scopus citations

Abstract

Src family tyrosine kinases (SFKs) are involved in a diverse array of physiological processes, as highlighted in this review. An overview of how SFKs interact with, and participate in signaling from, receptor tyrosine kinases (RTKs) is discussed. And also, how SFKs are activated by RTKs, and how SFKs, in turn, can activate RTKs, as well as how SFKs can promote signaling from growth factor receptors in a number of ways including participation in signaling pathways required for DNA synthesis, control of receptor turnover, actin cytoskeleton rearrangements and motility, and survival are discussed.

Original languageEnglish (US)
Pages (from-to)7957-7968
Number of pages12
JournalOncogene
Volume23
Issue number48 REV. ISS. 7
DOIs
StatePublished - Oct 18 2004
Externally publishedYes

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Keywords

  • Mitogenesis
  • Phosphotyrosine
  • Src
  • Survival
  • Ubiquitination

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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