The L33F darunavir resistance mutation acts as a molecular anchor reducing the flexibility of the HIV-1 protease 30s and 80s loops

Medicine & Life Sciences

• Darunavir 90%
• Human immunodeficiency virus 1 p16 protease 89%
• Peptide Hydrolases 40%
• Mutation 33%
• Polyproteins 16%
• Hydrogen Bonding 14%
• Hydrophobic and Hydrophilic Interactions 13%
• Life Cycle Stages 12%
• Protease Inhibitors 12%
• Drug Resistance 10%
• HIV-1 10%
• X-Rays 9%
• Amino Acids 8%
• Pharmaceutical Preparations 4%
• Proteins 4%
• Therapeutics 1%

Chemical Compounds

• Darunavir 100%
• Mutation 50%
• Flexibility 47%
• Resistance 37%
• Antiretroviral 17%
• Protease Inhibitor 14%
• Leaf Like Crystal 10%
• X-Ray 7%
• Protein 4%
• Acid 4%