TY - JOUR
T1 - The lncRNA PCAT29 inhibits oncogenic phenotypes in prostate cancer
AU - Malik, Rohit
AU - Patel, Lalit
AU - Prensner, John R.
AU - Shi, Yang
AU - Iyer, Matthew K.
AU - Subramaniyan, Shruthi
AU - Carley, Alexander
AU - Niknafs, Yashar S.
AU - Sahu, Anirban
AU - Han, Sumin
AU - Ma, Teng
AU - Liu, Meilan
AU - Asangani, Irfan A.
AU - Jing, Xiaojun
AU - Cao, Xuhong
AU - Dhanasekaran, Saravana M.
AU - Robinson, Dan R.
AU - Feng, Felix Y.
AU - Chinnaiyan, Arul M.
PY - 2014/8
Y1 - 2014/8
N2 - Long noncoding RNAs (lncRNA) have recently been associated with the development and progression of a variety of human cancers. However, to date, the interplay between known oncogenic or tumor-suppressive events and lncRNAs has not been well described. Here, the novel lncRNA, prostate cancer-associated transcript 29 (PCAT29), is characterized along with its relationship to the androgen receptor. PCAT29 is suppressed by DHT and upregulated upon castration therapy in a prostate cancer xenograft model. PCAT29 knockdown significantly increased proliferation and migration of prostate cancer cells, whereas PCAT29 overexpression conferred the opposite effect and suppressed growth and metastases of prostate tumors in chick chorioallantoic membrane assays. Finally, in prostate cancer patient specimens, low PCAT29 expression correlated with poor prognostic outcomes. Taken together, these data expose PCAT29 as an androgen-regulated tumor suppressor in prostate cancer.
AB - Long noncoding RNAs (lncRNA) have recently been associated with the development and progression of a variety of human cancers. However, to date, the interplay between known oncogenic or tumor-suppressive events and lncRNAs has not been well described. Here, the novel lncRNA, prostate cancer-associated transcript 29 (PCAT29), is characterized along with its relationship to the androgen receptor. PCAT29 is suppressed by DHT and upregulated upon castration therapy in a prostate cancer xenograft model. PCAT29 knockdown significantly increased proliferation and migration of prostate cancer cells, whereas PCAT29 overexpression conferred the opposite effect and suppressed growth and metastases of prostate tumors in chick chorioallantoic membrane assays. Finally, in prostate cancer patient specimens, low PCAT29 expression correlated with poor prognostic outcomes. Taken together, these data expose PCAT29 as an androgen-regulated tumor suppressor in prostate cancer.
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U2 - 10.1158/1541-7786.MCR-14-0257
DO - 10.1158/1541-7786.MCR-14-0257
M3 - Article
C2 - 25030374
AN - SCOPUS:84905962700
SN - 1541-7786
VL - 12
SP - 1081
EP - 1087
JO - Molecular Cancer Research
JF - Molecular Cancer Research
IS - 8
ER -