The localization of type 2 diabetes susceptibility gene loci in northern Chinese Han families

Jinying Zhao, Heng Wang, Momiao Xiong, Wei Huang, Jin Zuo, Zhu Chen, Boqin Qiang, Qi Sun, Yuxiu Li, Qiuying Liu, Weinan Du, Jialun Chen, Wei Ding, Wentao Yuan, Yang Zhao, Hongyan Xu, Li Jin, Fude Fang

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

We conducted a genome-wide scan, in which 358 well distributed fluorescent dye-labeled microsatellite marker sets were applied in 32 Chinese Han type 2 diabetes families from Northern China to search for the susceptibility gene loci. The data collected from screening all the chromosomes of genome were genotyped by using genescan and genotyping software, then, parametric and non-parametric multipoint test, and affected sib-pair analysis as well, were used to analyze the data. We identified some susceptibility gene loci residing in chromosomes 1,12,18,20, respectively, or precisely, located around D1S214, D1S207, D1S218, D1S235, D12S336, D18S61 and D20S118. The comparison of this result with those from other regions and races reflected the complexity and heterogeneity of type 2 diabetes.

Original languageEnglish (US)
Pages (from-to)1792-1795
Number of pages4
JournalChinese Science Bulletin
Volume45
Issue number19
DOIs
StatePublished - Jan 1 2000

Keywords

  • Northern Han Chinese
  • Susceptibility gene locus
  • Type 2 diabetes

ASJC Scopus subject areas

  • General

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  • Cite this

    Zhao, J., Wang, H., Xiong, M., Huang, W., Zuo, J., Chen, Z., Qiang, B., Sun, Q., Li, Y., Liu, Q., Du, W., Chen, J., Ding, W., Yuan, W., Zhao, Y., Xu, H., Jin, L., & Fang, F. (2000). The localization of type 2 diabetes susceptibility gene loci in northern Chinese Han families. Chinese Science Bulletin, 45(19), 1792-1795. https://doi.org/10.1007/BF02886269