TY - JOUR
T1 - The localization of type 2 diabetes susceptibility gene loci in northern Chinese Han families
AU - Zhao, Jinying
AU - Wang, Heng
AU - Xiong, Momiao
AU - Huang, Wei
AU - Zuo, Jin
AU - Chen, Zhu
AU - Qiang, Boqin
AU - Sun, Qi
AU - Li, Yuxiu
AU - Liu, Qiuying
AU - Du, Weinan
AU - Chen, Jialun
AU - Ding, Wei
AU - Yuan, Wentao
AU - Zhao, Yang
AU - Xu, Hongyan
AU - Jin, Li
AU - Fang, Fude
N1 - Funding Information:
Acknowledgements This work was supported by the National "973" Project and the National "863" High-Tech Project (Grant Nos. 102-10-02-02 and Z 19-0 1 -02-02).
PY - 2000
Y1 - 2000
N2 - We conducted a genome-wide scan, in which 358 well distributed fluorescent dye-labeled microsatellite marker sets were applied in 32 Chinese Han type 2 diabetes families from Northern China to search for the susceptibility gene loci. The data collected from screening all the chromosomes of genome were genotyped by using genescan and genotyping software, then, parametric and non-parametric multipoint test, and affected sib-pair analysis as well, were used to analyze the data. We identified some susceptibility gene loci residing in chromosomes 1,12,18,20, respectively, or precisely, located around D1S214, D1S207, D1S218, D1S235, D12S336, D18S61 and D20S118. The comparison of this result with those from other regions and races reflected the complexity and heterogeneity of type 2 diabetes.
AB - We conducted a genome-wide scan, in which 358 well distributed fluorescent dye-labeled microsatellite marker sets were applied in 32 Chinese Han type 2 diabetes families from Northern China to search for the susceptibility gene loci. The data collected from screening all the chromosomes of genome were genotyped by using genescan and genotyping software, then, parametric and non-parametric multipoint test, and affected sib-pair analysis as well, were used to analyze the data. We identified some susceptibility gene loci residing in chromosomes 1,12,18,20, respectively, or precisely, located around D1S214, D1S207, D1S218, D1S235, D12S336, D18S61 and D20S118. The comparison of this result with those from other regions and races reflected the complexity and heterogeneity of type 2 diabetes.
KW - Northern Han Chinese
KW - Susceptibility gene locus
KW - Type 2 diabetes
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U2 - 10.1007/BF02886269
DO - 10.1007/BF02886269
M3 - Article
AN - SCOPUS:0034477303
SN - 1001-6538
VL - 45
SP - 1792
EP - 1795
JO - Chinese Science Bulletin
JF - Chinese Science Bulletin
IS - 19
ER -