Abstract
A new gamma chain of human fetal hemoglobin, the M gamma chain, has been detected by high performance liquid chromatography (HPLC). It is characterized by a Leu----Met replacement at position gamma 141; no other structural variations have been found. The M gamma chain has been observed in red cell lysates of subjects with a heterozygosity for one of many types of hereditary persistence of fetal hemoglobin (HPFH), in sickle cell anemia, and in a few cord blood samples. At present, the genetic cause of this newly discovered heterogeneity is not known; an infidelity in translation or the existence of an unrecognized gamma globin gene should be considered.
Original language | English (US) |
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Pages (from-to) | 507-517 |
Number of pages | 11 |
Journal | Progress in clinical and biological research |
Volume | 251 |
State | Published - 1987 |
ASJC Scopus subject areas
- General Medicine