The melanocortinergic pathway is rapidly recruited by emotional stress and contributes to stress-induced anorexia and anxiety-like behavior

Jing Liu, Jacob C. Garza, Ha V. Truong, John Henschel, Wei Zhang, Xinyun Lu

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

Neurons producing melanocortin receptor agonist, α-MSH derived from proopiomelanocortin, and antagonist, agouti-related protein, are known to be sensitive to metabolic stress such as food deprivation and glucoprivation. However, how these neurons respond to emotional/psychological stress remained to be elucidated. We report here that acute emotional stressors, i.e. restraint and forced swim, evoked mRNA expression of c-fos, a neuronal activation marker, in a high percentage of proopiomelanocortin neurons (up to 53% for restraint stress and 62% for forced swim), with marked variations along the rostro-caudal axis of the arcuate nucleus. In contrast, only a small population of agouti-related protein neurons in this brain region was activated. These neuronal activation patterns were correlated with behavioral reactions. Both stressors suppressed feeding and induced anxietylike behavior in the elevated plus-maze test, as reflected by a reduction in the percentage of entries and time spent in the open arms. Central pretreatment with SHU9119, a melanocortin receptor antagonist, dose dependently attenuated the anorectic and anxiogenic effects elicited by acute restraint or forced swim. These results indicate that the melancortinergic pathway can be rapidly recruited by acute emotional stress, and that activation of melanocortin signaling is involved in mediating stress-induced anorexia and anxiety.

Original languageEnglish (US)
Pages (from-to)5531-5540
Number of pages10
JournalEndocrinology
Volume148
Issue number11
DOIs
StatePublished - Nov 1 2007
Externally publishedYes

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Anorexia
Psychological Stress
Anxiety
Agouti-Related Protein
Melanocortin Receptors
Neurons
Pro-Opiomelanocortin
Melanocortins
Melanocyte-Stimulating Hormones
Food Deprivation
Appetite Depressants
Arcuate Nucleus of Hypothalamus
Physiological Stress
Messenger RNA
Brain
Population

ASJC Scopus subject areas

  • Endocrinology

Cite this

The melanocortinergic pathway is rapidly recruited by emotional stress and contributes to stress-induced anorexia and anxiety-like behavior. / Liu, Jing; Garza, Jacob C.; Truong, Ha V.; Henschel, John; Zhang, Wei; Lu, Xinyun.

In: Endocrinology, Vol. 148, No. 11, 01.11.2007, p. 5531-5540.

Research output: Contribution to journalArticle

Liu, Jing ; Garza, Jacob C. ; Truong, Ha V. ; Henschel, John ; Zhang, Wei ; Lu, Xinyun. / The melanocortinergic pathway is rapidly recruited by emotional stress and contributes to stress-induced anorexia and anxiety-like behavior. In: Endocrinology. 2007 ; Vol. 148, No. 11. pp. 5531-5540.
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