The molecular basis of impaired follicle-stimulating hormone action: Evidence from human mutations and mouse models

Eric T. Siegel, Hyung Goo Kim, Hiromi Koso Nishimoto, Lawrence C. Layman

Research output: Contribution to journalReview article

42 Scopus citations

Abstract

The pituitary gonadotropin follicle-stimulating hormone (FSH) interacts with its membrane-bound receptor to produce biologic effects. Traditional functions of FSH include follicular development and estradiol production in females, and the regulation of Sertoli cell action and spermatogenesis in males. Knockout mice for both the ligand (Fshb) and the receptor (Fshr) serve as models for FSH deficiency, while Fshb and Fshr transgenic mice manifest FSH excess. In addition, inactivating mutations of both human orthologs (FSHB and FSHR) have been characterized in a small number of patients, with phenotypic effects of the ligand disruption being more profound than those of its receptor. Activating human FSHR mutants have also been described in both sexes, leading to a phenotype of normal testis function (male) or spontaneous ovarian hyperstimulation syndrome (females). As determined from human and mouse models, FSH is essential for normal puberty and fertility in females, particularly for ovarian follicular development beyond the antral stage. In males, FSH is necessary for normal spermatogenesis, but there are differences in human and mouse models. The FSHB mutations in humans result in azoospermia; while FSHR mutations in humans and knockouts of both the ligand and the receptor in mice affect testicular function but do not result in absolute infertility. Available evidence also indicates that FSH may also be necessary for normal androgen synthesis in males and females.

Original languageEnglish (US)
Pages (from-to)211-233
Number of pages23
JournalReproductive Sciences
Volume20
Issue number3
DOIs
StatePublished - Mar 1 2013

Keywords

  • FSH receptor
  • FSHB gene
  • FSHB knockout mouse
  • FSHB mutations
  • FSHB transgenic mouse
  • FSHR gene
  • FSHR knockout mouse
  • FSHR mutations
  • Follicle-stimulating hormone (FSH)
  • isolated FSH deficiency
  • ovarian hyperstimulation syndrome

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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