The molecular pathology of central neurocytomas

Ari J. Kane, Michael E. Sughrue, Martin J. Rutkowski, Tarik Tihan, Andrew T. Parsa

Research output: Contribution to journalReview article

15 Scopus citations

Abstract

Central neurocytomas (CN) are rare tumors. Since their first description in 1982, the number of case reports and series has been rapidly increasing. Although they are considered low-grade neoplasms, they can be associated with an aggressive primary course or recurrence after resection. The cellular origin of central neurocytoma (CN) and the molecular events leading to tumorigenesis have been largely unknown. Here, we present a review of the scientific literature contributing to our knowledge of CN focusing on cellular origin and oncogenic alterations, and how these findings inform areas amenable to future research and therapeutic intervention. Our discussion is expanded to include important and related insights into the cellular origin and classification of central nervous system tumors.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalJournal of Clinical Neuroscience
Volume18
Issue number1
DOIs
StatePublished - Jan 1 2011
Externally publishedYes

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Keywords

  • Cancer
  • Central neurocytoma
  • Chromosome
  • Gene
  • Molecular biology
  • Stem cell

ASJC Scopus subject areas

  • Surgery
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

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