The Neurobiological Basis for Social Affiliation in Autism Spectrum Disorder and Schizophrenia

Amanda Crider, Anilkumar Pillai

Research output: Contribution to journalArticle

Abstract

Social interaction and communication are complex behavioral paradigms involving many components. Many different neurotransmitters, hormones, sensory inputs, and brain regions are involved in the act of social engagement and verbal or nonverbal communication. Autism spectrum disorder (ASD) and schizophrenia are two neurodevelopmental disorders that have social and language deficits as hallmark symptoms but show very different etiologies. The output of social dysfunction is common to both ASD and schizophrenia, but this likely arises from very different pathophysiological means. This review will attempt to compile and interpret human and animal studies showing the neurobiological basis for the development of social and language deficits in ASD and schizophrenia as well as a comparison of the two disorders.

Original languageEnglish (US)
Pages (from-to)154-164
Number of pages11
JournalCurrent Behavioral Neuroscience Reports
Volume3
Issue number2
DOIs
StatePublished - Jun 1 2016

Keywords

  • Autism spectrum disorder
  • Language deficits
  • Neurodevelopmental disorders
  • Schizophrenia
  • Social affiliation
  • Social deficits

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Behavioral Neuroscience

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