The nuclear oncoproteins: RB and p53

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

A novel class of oncogene has been recognised whose loss-of-function results in the expression of the malignant phenotype. Two examples of such genes are the human retinoblastoma predisposition gene (RB1) and the gene encoding the cellular protein p53. These genes are thought to regulate and limit normal proliferation of cells and, as a consequence, can suppress tumongenicity when introduced into transformed cells. They are hence frequently described as 'tumour suppressor genes'. Both RB1 and p53 gene products are bound by various transforming early proteins encoded by the DNA tumour viruses SV40, adenovirus and human papilloma virus. It is thought that they are thus sequestered and rendered inactive. Thus, a coherent model is emerging whereby inactivation, either by mutation of sequestration, of these tumour suppressor genes may contribute to natural and experimental carcinogenic processes.

Original languageEnglish (US)
Pages (from-to)437-446
Number of pages10
JournalSeminars in Cancer Biology
Volume1
Issue number6
StatePublished - Dec 1 1990
Externally publishedYes

Fingerprint

Tumor Suppressor Protein p53
Tumor Suppressor Genes
Papillomaviridae
DNA Tumor Viruses
Genes
Retinoblastoma Genes
p53 Genes
Oncogenes
Adenoviridae
Proteins
Cell Proliferation
Phenotype
Mutation

Keywords

  • Anti-oncogene
  • p53
  • RB
  • Retinoblastoma gene
  • Tumour suppressor genes

ASJC Scopus subject areas

  • Cancer Research

Cite this

The nuclear oncoproteins : RB and p53. / Cowell, John Kenneth.

In: Seminars in Cancer Biology, Vol. 1, No. 6, 01.12.1990, p. 437-446.

Research output: Contribution to journalArticle

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