The percentage of CD31+ T cells decreases after open but not laparoscopic surgery

I. Kirman, V. Cekic, N. Poltaratskaia, Z. Asi, S. Conte, D. Feingold, K. A. Forde, E. H. Huang, R. L. Whelan

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background: Efficient killing of tumor cells depends on T cells that migrate from the circulation to the peripheral tissues; these cells express CD31. This study was undertaken to determine the impact of open (OS) and laparoscopic (LS) colorectal surgery on the percentage of circulating CD3+ CD31+ cells. Methods: Peripheral blood was collected from 27 OS and 24 LS colon cancer patients preoperatively (preOP) and on postoperative days 1 (POD1) and 3 (POD3). CD31+ T cells were assessed by flow cytometry using monoclonal antibodies. Results: In the OS group, the percentage of CD3+ CD31+ cells was significantly lower in POD1 and POD3 samples compared to the preOP results. LS surgery did not result in a significant change in the percentage of these T cells. A significant correlation was found between the decrease in the percentage of CD3+ CD31+ cells and the length of incision in OS patients. Conclusions: The percentage of CD3+ CD31+ cells decreases following OS but not LS and may be related to incision length. This may compromise T cell function in the peripheral tissues in the postoperative period.

Original languageEnglish (US)
Pages (from-to)754-757
Number of pages4
JournalSurgical Endoscopy and Other Interventional Techniques
Volume17
Issue number5
DOIs
StatePublished - May 1 2003

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Laparoscopy
T-Lymphocytes
Colorectal Surgery
Postoperative Period
Colonic Neoplasms
Flow Cytometry
Monoclonal Antibodies
Neoplasms

Keywords

  • CD31
  • Immune function
  • Laparoscopy
  • T cells

ASJC Scopus subject areas

  • Surgery

Cite this

Kirman, I., Cekic, V., Poltaratskaia, N., Asi, Z., Conte, S., Feingold, D., ... Whelan, R. L. (2003). The percentage of CD31+ T cells decreases after open but not laparoscopic surgery. Surgical Endoscopy and Other Interventional Techniques, 17(5), 754-757. https://doi.org/10.1007/s00464-002-8942-3

The percentage of CD31+ T cells decreases after open but not laparoscopic surgery. / Kirman, I.; Cekic, V.; Poltaratskaia, N.; Asi, Z.; Conte, S.; Feingold, D.; Forde, K. A.; Huang, E. H.; Whelan, R. L.

In: Surgical Endoscopy and Other Interventional Techniques, Vol. 17, No. 5, 01.05.2003, p. 754-757.

Research output: Contribution to journalArticle

Kirman, I, Cekic, V, Poltaratskaia, N, Asi, Z, Conte, S, Feingold, D, Forde, KA, Huang, EH & Whelan, RL 2003, 'The percentage of CD31+ T cells decreases after open but not laparoscopic surgery', Surgical Endoscopy and Other Interventional Techniques, vol. 17, no. 5, pp. 754-757. https://doi.org/10.1007/s00464-002-8942-3
Kirman, I. ; Cekic, V. ; Poltaratskaia, N. ; Asi, Z. ; Conte, S. ; Feingold, D. ; Forde, K. A. ; Huang, E. H. ; Whelan, R. L. / The percentage of CD31+ T cells decreases after open but not laparoscopic surgery. In: Surgical Endoscopy and Other Interventional Techniques. 2003 ; Vol. 17, No. 5. pp. 754-757.
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