The percentage of CD31+ T cells decreases after open but not laparoscopic surgery

I. Kirman, V. Cekic, N. Poltaratskaia, Z. Asi, Stephane A Conte, D. Feingold, K. A. Forde, E. H. Huang, R. L. Whelan

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background: Efficient killing of tumor cells depends on T cells that migrate from the circulation to the peripheral tissues; these cells express CD31. This study was undertaken to determine the impact of open (OS) and laparoscopic (LS) colorectal surgery on the percentage of circulating CD3+ CD31+ cells. Methods: Peripheral blood was collected from 27 OS and 24 LS colon cancer patients preoperatively (preOP) and on postoperative days 1 (POD1) and 3 (POD3). CD31+ T cells were assessed by flow cytometry using monoclonal antibodies. Results: In the OS group, the percentage of CD3+ CD31+ cells was significantly lower in POD1 and POD3 samples compared to the preOP results. LS surgery did not result in a significant change in the percentage of these T cells. A significant correlation was found between the decrease in the percentage of CD3+ CD31+ cells and the length of incision in OS patients. Conclusions: The percentage of CD3+ CD31+ cells decreases following OS but not LS and may be related to incision length. This may compromise T cell function in the peripheral tissues in the postoperative period.

Original languageEnglish (US)
Pages (from-to)754-757
Number of pages4
JournalSurgical Endoscopy and Other Interventional Techniques
Volume17
Issue number5
DOIs
StatePublished - May 1 2003

Fingerprint

Laparoscopy
T-Lymphocytes
Colorectal Surgery
Postoperative Period
Colonic Neoplasms
Flow Cytometry
Monoclonal Antibodies
Neoplasms

Keywords

  • CD31
  • Immune function
  • Laparoscopy
  • T cells

ASJC Scopus subject areas

  • Surgery

Cite this

Kirman, I., Cekic, V., Poltaratskaia, N., Asi, Z., Conte, S. A., Feingold, D., ... Whelan, R. L. (2003). The percentage of CD31+ T cells decreases after open but not laparoscopic surgery. Surgical Endoscopy and Other Interventional Techniques, 17(5), 754-757. https://doi.org/10.1007/s00464-002-8942-3

The percentage of CD31+ T cells decreases after open but not laparoscopic surgery. / Kirman, I.; Cekic, V.; Poltaratskaia, N.; Asi, Z.; Conte, Stephane A; Feingold, D.; Forde, K. A.; Huang, E. H.; Whelan, R. L.

In: Surgical Endoscopy and Other Interventional Techniques, Vol. 17, No. 5, 01.05.2003, p. 754-757.

Research output: Contribution to journalArticle

Kirman, I, Cekic, V, Poltaratskaia, N, Asi, Z, Conte, SA, Feingold, D, Forde, KA, Huang, EH & Whelan, RL 2003, 'The percentage of CD31+ T cells decreases after open but not laparoscopic surgery', Surgical Endoscopy and Other Interventional Techniques, vol. 17, no. 5, pp. 754-757. https://doi.org/10.1007/s00464-002-8942-3
Kirman, I. ; Cekic, V. ; Poltaratskaia, N. ; Asi, Z. ; Conte, Stephane A ; Feingold, D. ; Forde, K. A. ; Huang, E. H. ; Whelan, R. L. / The percentage of CD31+ T cells decreases after open but not laparoscopic surgery. In: Surgical Endoscopy and Other Interventional Techniques. 2003 ; Vol. 17, No. 5. pp. 754-757.
@article{6ada4db78fd34359a4f4cc1e2d8ba415,
title = "The percentage of CD31+ T cells decreases after open but not laparoscopic surgery",
abstract = "Background: Efficient killing of tumor cells depends on T cells that migrate from the circulation to the peripheral tissues; these cells express CD31. This study was undertaken to determine the impact of open (OS) and laparoscopic (LS) colorectal surgery on the percentage of circulating CD3+ CD31+ cells. Methods: Peripheral blood was collected from 27 OS and 24 LS colon cancer patients preoperatively (preOP) and on postoperative days 1 (POD1) and 3 (POD3). CD31+ T cells were assessed by flow cytometry using monoclonal antibodies. Results: In the OS group, the percentage of CD3+ CD31+ cells was significantly lower in POD1 and POD3 samples compared to the preOP results. LS surgery did not result in a significant change in the percentage of these T cells. A significant correlation was found between the decrease in the percentage of CD3+ CD31+ cells and the length of incision in OS patients. Conclusions: The percentage of CD3+ CD31+ cells decreases following OS but not LS and may be related to incision length. This may compromise T cell function in the peripheral tissues in the postoperative period.",
keywords = "CD31, Immune function, Laparoscopy, T cells",
author = "I. Kirman and V. Cekic and N. Poltaratskaia and Z. Asi and Conte, {Stephane A} and D. Feingold and Forde, {K. A.} and Huang, {E. H.} and Whelan, {R. L.}",
year = "2003",
month = "5",
day = "1",
doi = "10.1007/s00464-002-8942-3",
language = "English (US)",
volume = "17",
pages = "754--757",
journal = "Surgical Endoscopy and Other Interventional Techniques",
issn = "0930-2794",
publisher = "Springer New York",
number = "5",

}

TY - JOUR

T1 - The percentage of CD31+ T cells decreases after open but not laparoscopic surgery

AU - Kirman, I.

AU - Cekic, V.

AU - Poltaratskaia, N.

AU - Asi, Z.

AU - Conte, Stephane A

AU - Feingold, D.

AU - Forde, K. A.

AU - Huang, E. H.

AU - Whelan, R. L.

PY - 2003/5/1

Y1 - 2003/5/1

N2 - Background: Efficient killing of tumor cells depends on T cells that migrate from the circulation to the peripheral tissues; these cells express CD31. This study was undertaken to determine the impact of open (OS) and laparoscopic (LS) colorectal surgery on the percentage of circulating CD3+ CD31+ cells. Methods: Peripheral blood was collected from 27 OS and 24 LS colon cancer patients preoperatively (preOP) and on postoperative days 1 (POD1) and 3 (POD3). CD31+ T cells were assessed by flow cytometry using monoclonal antibodies. Results: In the OS group, the percentage of CD3+ CD31+ cells was significantly lower in POD1 and POD3 samples compared to the preOP results. LS surgery did not result in a significant change in the percentage of these T cells. A significant correlation was found between the decrease in the percentage of CD3+ CD31+ cells and the length of incision in OS patients. Conclusions: The percentage of CD3+ CD31+ cells decreases following OS but not LS and may be related to incision length. This may compromise T cell function in the peripheral tissues in the postoperative period.

AB - Background: Efficient killing of tumor cells depends on T cells that migrate from the circulation to the peripheral tissues; these cells express CD31. This study was undertaken to determine the impact of open (OS) and laparoscopic (LS) colorectal surgery on the percentage of circulating CD3+ CD31+ cells. Methods: Peripheral blood was collected from 27 OS and 24 LS colon cancer patients preoperatively (preOP) and on postoperative days 1 (POD1) and 3 (POD3). CD31+ T cells were assessed by flow cytometry using monoclonal antibodies. Results: In the OS group, the percentage of CD3+ CD31+ cells was significantly lower in POD1 and POD3 samples compared to the preOP results. LS surgery did not result in a significant change in the percentage of these T cells. A significant correlation was found between the decrease in the percentage of CD3+ CD31+ cells and the length of incision in OS patients. Conclusions: The percentage of CD3+ CD31+ cells decreases following OS but not LS and may be related to incision length. This may compromise T cell function in the peripheral tissues in the postoperative period.

KW - CD31

KW - Immune function

KW - Laparoscopy

KW - T cells

UR - http://www.scopus.com/inward/record.url?scp=0038414863&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0038414863&partnerID=8YFLogxK

U2 - 10.1007/s00464-002-8942-3

DO - 10.1007/s00464-002-8942-3

M3 - Article

VL - 17

SP - 754

EP - 757

JO - Surgical Endoscopy and Other Interventional Techniques

JF - Surgical Endoscopy and Other Interventional Techniques

SN - 0930-2794

IS - 5

ER -